JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v2i4.2164 jpsim.v2i4.2164 Review Article Granulomatosis with Polyangiitis (GPA) / Wegner's Granulomatosis: A Summary of Clinical Issues Hussain Asif drasifhussain@gmail.com * Javaid Muhammad M Avais Jawaria Australian Medical Council, Epping Medical Specialist Centre Monash University, Southwest Regional Hospital, Victoria, Australia *Correspondence: Asif Hussain (drasifhussain@gmail.com) 14 12 2021 2021 2 4 284 292 04 09 2021 06 10 2021 Copyright © 2021 The Author(s) 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Vasculitis can mimic many diseases; often, there are delays in diagnosis and often ends up in life/organ threatening complications without proper diagnosis and timely treatment. Patients can present with various combinations of constitutional symptoms, vasculitic symptoms, and organ involvements. ANCA tests also have many false positive and false negative results, which adds to the complexity. In addition, Anti-neutrophilic Cytoplasmic Antibody (ANCA) associated Vasculitis (AAV) have different pathological and clinical manifestations from other Vasculitis. There are four types of AAV, including Granulomatosis with Polyangiitis (GPA, previously known as Wegner's Granulomatosis), Microscopic Polyangiitis (MPA), Eosinophilic Granulomatosis with Polyangiitis (E-GPA, previously called as Churg Strauss Vasculitis), and Renal Limited / Organ limited ANCA associated Vasculitis

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