JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v2i4.2167 jpsim.v2i4.2167 Original Research Positive Predictive Value of Thrombocytopenia and Leukopenia in Diagnosis of Acute Dengue Infection Behzad Rafia dr.waqas099@gmail.com * Khalid Aatika Fauji Foundation Hospital, Rawalpindi *Correspondence: Rafia Behzad (dr.waqas099@gmail.com) 14 12 2021 2021 2 4 304 307 17 08 2021 02 11 2021 Copyright © 2021 The Author(s) 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To determine the positive predictive value of thrombocytopenia and leukopenia in patients of acute dengue

infection.

 Methodology

This descriptive study was undertaken in Haematology Department, Medical and Pediatric wards, Fauji

Foundation Hospital, Rawalpindi. A total of 100 patients diagnosed as a case of acute dengue infection on the basis of

Indirect ELISA for anti DENV IgM were selected using inclusion and exclusion criteria. Venous blood of 2.5 ml of these

patients was collected in CP bottle containing EDTA as anticoagulant. It was analyzed on automated Haematology

analyzer Sysmex XT 2000i system. Blood levels of Total Leucocyte Count and platelet count were recorded and

documented for these patients and their positive predictive values were calculated.

 Results

Out of 100 diagnosed patients of acute dengue infection, 81% exhibited thrombocytopenia and 75% had

leukopenia. The combined PPVof leukopenia and thrombocytopenia was 88%.

 Conclusion

Acute dengue fever is characterized by thrombocytopenia and leukopenia. Therefore Dengue should be the

top most differential diagnosis in febrile patients with thrombocytopenia and leucopenia.

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