On 30th January 2020, the World Health Organization (WHO) announced COVID-19 outbreak as the sixth public health emergency of international concern (PHEIC), and on March 11, 2020, the WHO declared COVID-19 as pandemic naming the corona virus disease (COVID-19) and the virus that causes it. SARS-CoV-2 has recently emerged as a global threat, directly affecting human life owing to its morbidity and mortality and indirectly, due to the enormous economic and psychological impact produced by social isolation, the most effective measure so far. From March 2020 to early 2022, many variants of SARSC0V-2 have been identified driving different waves of COVID-19. Every single day we hear about some new variant with more rapid transmission rate and more severity. Currently the world is facing another wave of covid-19 because of omicron variant which was initially said to be milder disease intensity variant but highly transmissible. Experts were of the opinion of building herd immunity and getting covid-19 limited to some specific areas in the form of a milder ENDEMIC disease in future with variants like omicron. But every single day, exploding surge in omicron cases n mortalities make us all question the concept of pandemicity to endemicity. Meanwhile all we can do to lessen the burden caused by COVID -19 is to vaccinate more n more people, booster doses and to take help of some new antiviral drugs with proven efficacy along with social distancing and mask wearing.