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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v3i2.2221</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v3i2.2221</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Review Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Pulmonary and Extra-Pulmonary Complications of COVID-19: A Literature Review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Ibrahim</surname>
            <given-names>Muhammad</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ayaz</surname>
            <given-names>Ahmed</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Arshad</surname>
            <given-names>Ainan</given-names>
          </name>
          <email>ainan_arshad@hotmail.com</email>
          <xref ref-type="aff" rid="aff2"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Hussain</surname>
            <given-names>Erfan</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Jamil</surname>
            <given-names>Bushra</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Karachi Grammar College</institution>
      </aff>
      <aff id="aff2">
        <institution>Aga Khan University, Karachi, Pakistan</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Ainan Arshad (ainan_arshad@hotmail.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2022-06-15">
        <day>15</day>
        <month>06</month>
        <year>2022</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2022</year>
      </pub-date>
      <volume>3</volume>
      <issue>2</issue>
      <fpage>109</fpage>
      <lpage>116</lpage>
      <history>
        <date date-type="received" iso-8601-date="2022-01-17">
          <day>17</day>
          <month>01</month>
          <year>2022</year>
        </date>
        <date date-type="accepted" iso-8601-date="2022-03-30">
          <day>30</day>
          <month>03</month>
          <year>2022</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2022 The Author(s)</copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v3i2.2221" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v3i2.2221.pdf" content-type="application/pdf"/>
      <abstract>
        <p>Although scientific innovation in the modern age has led the way for crucial breakthroughs in the field of medicine, human beings have not yet been able to tame burgeoning infectious threats. Initial studies had shown that elderly patients and those with a higher comorbidity burden had a worse prognosis when compared to their younger and healthier counterparts. The former were also at a higher risk of developing pulmonary complications such as Acute Respiratory Distress Syndrome (ARDS) and cytokine storm to devastating effect. Later on, it was discovered that this virus can also affect several extra-pulmonary organs and cause cardiac, neurological, thrombotic, dermatological and gastrointestinal complications. The purpose of this review article is to summarize current evidence on short and long term complications of COVID-19 in a system-wise manner to serve as a guide for all healthcare providers around the world for early detection, prevention and timely management of such complications.</p>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Covid-19</kwd>
        <kwd>pneumonia</kwd>
        <kwd>cytokine storm</kwd>
        <kwd>complications</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <!-- <body> omitted: no manuscript (.docx) on file -->
  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
        <mixed-citation>COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). [Updated 2021, cited 2022] Available from [https://www.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6].</mixed-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <mixed-citation>Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.</mixed-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <mixed-citation>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.</mixed-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <mixed-citation>Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ; HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033-4.</mixed-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <mixed-citation>Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) Infection Chapter 14. p.189-95.</mixed-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <mixed-citation>Haimei MA. Pathogenesis and Treatment Strategies of COVID-19-Related Hypercoagulant and Thrombotic Complications. Clin Appl Thromb. 2020;26(168):1-5.</mixed-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <mixed-citation>Kochi AN, Tagliari AP, Forleo GB, Fassini GM, Tondo C. Cardiac and arrhythmic complications in patients with COVID-19. J Cardiovasc Electrophysiol. 2020;31(5):1003-8.</mixed-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <mixed-citation>Wu J, Song S, Cao HC, Li LJ. Liver diseases in COVID-19: Etiology, treatment and prognosis. World J Gastroenterol. 2020;26(19):2286-93.</mixed-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <mixed-citation>Ye Q, Wang B, Mao J. The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information. [Updated November 2021, cited 202] Available from: [https://www.elsevier.com/connect/coronavirus-information-center].</mixed-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <mixed-citation>Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395(10223):507-13.</mixed-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <mixed-citation>Ayaz A, Arshad A, Malik H, Ali H, Hussain E, Jamil B. Risk factors for intensive care unit admission and mortality in hospitalized COVID-19 patients. Acute Crit Care. 2020;35(4):249–54.</mixed-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <mixed-citation>Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical characteristics of Covid-19 in New York City. N Engl J Med. 2020;382:2372-4.</mixed-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <mixed-citation>Ahmadpoor P, Rostaing L. Why the immune system fails to mount an adaptive immune response to a Covid-19 infection. Transplant International. 2020; 33(7):824-5.</mixed-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <mixed-citation>Teijaro JR, Walsh KB, Rice S, Rosen H, Oldstone MB. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection. Proc. Natl. Acad Sci. 2014;111(10):3799-804.</mixed-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <mixed-citation>Ye Q, Wang B, Mao J. The pathogenesis and treatment of the ‘Cytokine Storm’’ in COVID-19. J. Infect. 2020;80(6):607-13.’</mixed-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <mixed-citation>Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. Cytokine release syndrome in Severe COVID-19; Interleukin-6 receptor (IL-6R) Antagonist Tocilizumab may be the key to reduce the mortality. Int J Antimicrob Agents. 2020;55(5):105954.</mixed-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <mixed-citation>Zain Mushtaq M, Bin Zafar Mahmood S, Jamil B, Aziz A, Ali SA. Outcome of COVID-19 patients with use of Tocilizumab: A single center experience. Int Immunopharmacol. 2020; <pub-id pub-id-type="doi">10.1016/j.intimp.2020.106926</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <mixed-citation>Witting C, Quaggin-Smith J, Mylvaganam R, Peigh G, Angarone M, Flaherty JD. Invasive pulmonary aspergillosis after treatment with tocilizumab in a patient with COVID-19 ARDS: a case report. Diagn Microbiol Infect Dis. 2021;99(4):115272.</mixed-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <mixed-citation>Prattes J, Valentin T, Hoenigl M, Talakic E, Reisinger AC, Eller P. Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report. Med Mycol Case Rep. 2020 <pub-id pub-id-type="doi">10.1016/j.mmcr.2020.05.001</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <mixed-citation>Patti RK, Dalsania NR, Somal N, Sinha A, Mehta S, Ghitan M, Seneviratne C, Kupfer Y. Subacute Aspergillosis “Fungal Balls” Complicating COVID-19. J Investig Med High Impact Case Rep. 2020 ;<pub-id pub-id-type="doi">10.1177/2324709620966475</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <mixed-citation>Shadrach BJ, Goel R, Deokar K, Jain A. Invasive pulmonary aspergillosis in a COVID-19 recovered patient: Unravelling an infective sequalae of the SARS-CoV-2 virus. Monaldi Archives for Chest Disease. 2021 Apr 6;91(2):41-54.</mixed-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <mixed-citation>Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109(5):531–8.</mixed-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <mixed-citation>Arentz, Matt et al. “Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State.” JAMA. 2020;323(16): 1612-4.</mixed-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <mixed-citation>Bansal M. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19 . The COVID-19 resource centre is hosted on Elsevier Connect , the company ’ s public news and information. 2020;14(3):247–50.</mixed-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <mixed-citation>de Seze J. The neurological manifestations of COVID-19. Prat Neurol - FMC. 2020;11(3):145–6.</mixed-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <mixed-citation>Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia ZJJGIM. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19):1–5. 2020;<pub-id pub-id-type="doi">10.1007/s11606-020-05762-w</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <mixed-citation>Azhideh A. COVID-19 Neurological Manifestations. Int Clin Neurosci J.2020;7(2):54.</mixed-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <mixed-citation>Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34(1):101623.</mixed-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <mixed-citation>Wang Y, Wang Y, Chen Y, Qin QJJ. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 2020;92(6):25748.</mixed-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <mixed-citation>Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;<pub-id pub-id-type="doi">10.1016/j</pub-id>. bbi.2020.03.031.</mixed-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <mixed-citation>Karimi N, Sharifi Razavi A. Rouhani NJIRCMJ. Frequent convulsive seizures in an adult patient with COVID-19: a case report. Iran Red Crescent Med J. 2020;https://doi.org/10. 5812/ircmj.102828.</mixed-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <mixed-citation>Sedaghat Z, Karimi N. Guillain Barre syndrome associated with COVID-19 infection: a case report. J Clin Neurosci. 2020;https:// doi.org/<pub-id pub-id-type="doi">10.1016/j.jocn.2020.04.062</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <mixed-citation>Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome. Rhinology. 2020;https:// doi.org/<pub-id pub-id-type="doi">10.4193/rhin20.114</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <mixed-citation>Thompson A, Morgan C, Smith P, Jones C, Ball H, Coulthard EJ, Moran E, Szewczyk-Krolikowski K, Rice CM. Cerebral venous sinus thrombosis associated with COVID-19. Pract Neurol. 2020; <pub-id pub-id-type="doi">10.1136/practneurol-2020-002678</pub-id>. Epub.</mixed-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <mixed-citation>Fares E, Tayyar R, Pathak K, Damiano C, Kuntz C. Myasthenia Gravis Crisis Triggered By Covid-19. Chest. 2020;158(4):A734.</mixed-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <mixed-citation>] Lodigiani C, Iapichino G, Carenzo L. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191(1):9-14.</mixed-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <mixed-citation>Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18(6):1421–4.</mixed-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <mixed-citation>Andrea V, Gianluca F, Rodolfo P, Paolo T, Alessandro P, Mauro G. Unheralded lower limb threatening ischemia in a COVID-19 patient. Int J Infect Dis. 2020;9712(20):S1201.</mixed-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <mixed-citation>Kashi M, Jacquin A, Dakhil B, et al. Severe arterial thrombosis associated with Covid19 infection. Thromb Res. 2020;192(1):75–7.</mixed-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <mixed-citation>Bellosta R, Luzzani L, Natalini G. Acute limb ischemia in patients with COVID-19 pneumonia. J Vasc Surg. 2020; <pub-id pub-id-type="doi">10.1016/j.jvs.2020.04.483</pub-id> 31080-6.</mixed-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <mixed-citation>Kaur P, Posimreddy S, Singh B, et al. COVID-19 presenting as acute limb ischaemia. Eur J Case Rep Intern Med. 2020;7(6):001724.</mixed-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <mixed-citation>Gomez-Arbelaez D, Ibarra-Sanchez G, Garcia-Gutierrez A, Comanges-Yeboles A, Ansuategui-Vicente M, Gonzalez-Fajardo JA. Covid-19-related aortic thrombosis: a report of four cases. Ann Vasc Surg. 2020;67(3):10-3.</mixed-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <mixed-citation>Watson RA, Johnson DM, Dharia RN, Merli GJ, Doherty JU. Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system. Hosp Prac. 2020;48(4):169-79.</mixed-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <mixed-citation>Di Minno A, Ambrosino P, Calcaterra I, Di Minno MND. COVID-19 and venous thromboembolism: a meta-analysis of literature studies. Semin Thromb Hemost. 2020. <pub-id pub-id-type="doi">10.1055/s-0040-</pub-id> 1715456.</mixed-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <mixed-citation>Qureshi AI, Abd-Allah F, Alsenani F. Management of acute ischemic stroke in patients with COVID-19 infection: report of an international panel. Int J Stroke. 2020; https://doi.org/10.1177/ 17474930209.</mixed-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <mixed-citation>Wang Z, Yang B, Li Q, Wen L, Zhang R. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Clin Infect Dis 2020;<pub-id pub-id-type="doi">10.1093/cid/ciaa272</pub-id></mixed-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <mixed-citation>Zhang B, Zhou X, Qiu Y, Feng F, Feng J, Jia Y, Zhu H, Hu K, Liu J, Liu Z, Wang S. Clinical characteristics of 82 death cases with COVID-19. medRxiv. 2020. Google Scholar. 2020. doi: <pub-id pub-id-type="doi">10.1101/2020.02.26.20028191</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <mixed-citation>Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARSCoV-2 possible? Lancet Gastroenterol Hepatol. 2020; 5(3): 335-7.</mixed-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <mixed-citation>Tan YJ, Fielding BC, Goh PY, Shen S, Tan TH, Lim SG, Hong W. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J Virol 2004; 78(24):14043-7.</mixed-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <mixed-citation>Hu LL, Wang WJ, Zhu QJ, Yang L. Novel coronavirus pneumonia-related liver injury: etiological analysis and treatment strategy. Zhonghua Gan Zang Bing Za Zhi. 2020;28(2):97-99.</mixed-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <mixed-citation>Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020;20(5):269-70.</mixed-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <mixed-citation>Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020; 8(4): 420.</mixed-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <mixed-citation>Recalcati, S. Cutaneous manifestations in COVID‐19: a first perspective. J Eur Acad Dermatol Venereol.2020; <pub-id pub-id-type="doi">10.1111/jdv.16387</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <mixed-citation>Galván Casas C, Catala AC, Carretero Hernández G, Rodríguez‐Jiménez P, Fernández‐Nieto D, Rodríguez‐Villa Lario A et al. Classification of the cutaneous manifestations of COVID‐19: a rapid prospective nationwide consensus study in Spain with 375 cases. British J Dermatol. 2020;183(1):71-7.</mixed-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <mixed-citation>Hedou M, Carsuzaa F, Chary E, Hainaut E, Cazenave-Roblot F, Masson Regnault M. Comment on “Cutaneous manifestations in COVID-19: a first perspective” by Recalcati S. J Eur Acad Dermatol Venereol. 2020;34(7):e299-e300.</mixed-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <mixed-citation>Donnelly JP, Wang XQ, Iwashyna TJ, Prescott HC. Readmission and Death After Initial Hospital Discharge Among Patients With COVID-19 in a Large Multihospital System. JAMA. 2020; <pub-id pub-id-type="doi">10.1001/jama.2020.21465</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <mixed-citation>Lavery AM, Preston LE, Ko JY, Chevinsky JR, DeSisto CL, Pennington AFet al. Characteristics of hospitalized COVID-19 patients discharged and experiencing same-hospital readmission—United States, March–August 2020. Morbid Mortal Weekly Report. 2020;69(45):1695.</mixed-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <mixed-citation>Rokadiya S, Gil E, Stubbs C, Bell D, Herbert R. COVID-19: Outcomes of patients with confirmed COVID-19 re-admitted to hospital. J Infect. 2020;81(3):e18-e19.</mixed-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <mixed-citation>Atalla, E, Kalligeros, M, Giampaolo, G, Mylona, EK, Shehadeh, F, Mylonakis, E. Readmissions among patients with COVID-19. Int J Clin Pract. 2020; <pub-id pub-id-type="doi">10.1111/ijcp.13700</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <mixed-citation>Somani SS, Richter F, Fuster V, De Freitas JK, Naik N, Sigel K et al. Characterization of patients who return to hospital following discharge from hospitalization for COVID-19. J Gen Intern Med. 2020;35(10):2838-44.</mixed-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <mixed-citation>Parra LM, Cantero M, Morrás I. Hospital Readmissions of Discharged Patients with COVID-19. Int J Gen Med. 2020; <pub-id pub-id-type="doi">10.2147/IJGM.S275775</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <mixed-citation>Villar J, Confalonieri M, Pastores SM. Rationale for prolonged corticosteroid treatment in the acute respiratory distress syndrome caused by coronavirus disease 2019. Crit Care Explor. 2020;2(4):e0111.</mixed-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <mixed-citation>Horby P, Lim WS, Emberson JR. Dexamethasone in hospitalized patients with covid-19: preliminary report. N Engl J Med. 2020;<pub-id pub-id-type="doi">10.1056/NEJMoa2021436</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <mixed-citation>van Paassen, J., Vos, J.S., Hoekstra, E.M. et al. Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes. Crit Care. 2020; <pub-id pub-id-type="doi">10.1186/s13054-020-03400-9</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <mixed-citation>Li H, Chen C, Hu F, et al. Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis. Leukemia. 2020;34(6):1503–11.</mixed-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <mixed-citation>Singh AK, Majumdar S, Singh R. Role of corticosteroid in the management of COVID-19: A systemic review and a Clinician’s perspective. Diabetes Metab Syndr. 2020;14(5):971–8.</mixed-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <mixed-citation>Arabi YM, Mandourah Y, Al-Hameed F. Corticosteroid therapy for critically ill patients with Middle East Respiratory Syndrome. Am J Respir Crit Care Med. 2018;197(6):757–67.</mixed-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <mixed-citation>Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet. 2020;395(10223):473–5.</mixed-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <mixed-citation>Ma Y, Zeng H, Zhan Z, et al. Corticosteroid use in the treatment of COVID-19: a multicenter retrospective study in hunan, China. Front Pharmacol. 2020;11(10):1198.</mixed-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <mixed-citation>Sarkar S, Khanna P, Soni KD. Are the steroids a blanket solution for COVID-19? A systematic review and meta-analysis. J Med Virol. 2021;93(3):1538-47.</mixed-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <mixed-citation>Torales J, O’Higgins M, Castaldelli-Maia JM, Ventriglio A. The outbreak of COVID-19 coronavirus and its impact on global mental health. Int J Soc Psychiatry. 2020;66(4):317-320.</mixed-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <mixed-citation>Vindegaard N, Benros ME. COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav Immun. 2020 Oct;89:531-42.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
