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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v3i4.2263</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v3i4.2263</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Compare the Mean Blood Loss during a Term Caesarean Delivery in Primigravidas using Sublingual Misoprostol with an Intravenous Oxytocin Infusion</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Maqsood</surname>
            <given-names>Maria</given-names>
          </name>
          <email>docmaria0777@gmail.com</email>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Maqsood</surname>
            <given-names>Shumaila</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Nasir</surname>
            <given-names>Kiran</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Zafar</surname>
            <given-names>Hina</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Saeed</surname>
            <given-names>Furqan</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Waheed</surname>
            <given-names>Iqra</given-names>
          </name>
          <xref ref-type="aff" rid="aff4"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Lady Aitchison Hospital, Lahore</institution>
      </aff>
      <aff id="aff2">
        <institution>DHQ Hospital Mianwali</institution>
      </aff>
      <aff id="aff3">
        <institution>Mayo Hospital Lahore</institution>
      </aff>
      <aff id="aff4">
        <institution>Biostatistician</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Maria Maqsood (docmaria0777@gmail.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2022-12-18">
        <day>18</day>
        <month>12</month>
        <year>2022</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2022</year>
      </pub-date>
      <volume>3</volume>
      <issue>4</issue>
      <fpage>324</fpage>
      <lpage>327</lpage>
      <history>
        <date date-type="received" iso-8601-date="2022-07-23">
          <day>23</day>
          <month>07</month>
          <year>2022</year>
        </date>
        <date date-type="accepted" iso-8601-date="2022-09-27">
          <day>27</day>
          <month>09</month>
          <year>2022</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2022 The Author(s)</copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v3i4.2263" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v3i4.2263.pdf" content-type="application/pdf"/>
      <abstract>
        <sec>
          <title>Objective</title>
          <p>The objective was to compare the mean1blood loss using sublingual misoprostol and intravenous oxytocin infusion in primigravidas undergoing caesarean section at term.</p>
        </sec>
        <sec>
          <title>Methodology</title>
          <p>This Randomized Controlled Trial was done on 200 pregnant females who were later on randomly divided into two equal groups. The caesarean sections were performed via the transperitoneal approach. Within 2 hours, blood loss was noted. Data was entered &amp; analyzed on SPSS V 21.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>The mean1age was 26.29±5.32 years. The mean blood loss was 169.47±35.80ml. The significant difference between the groups with mean blood loss of the1patients i.e. p-value = 0.000.</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>The use of sublingual misoprostol for management of blood loss is more effective than oxytocin in primigravida undergoing caesarean delivery</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Postpartum hemorrhage</kwd>
        <kwd>Blood Loss</kwd>
        <kwd>Misoprostol</kwd>
        <kwd>Oxytocin</kwd>
        <kwd>Caesarean Delivery</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <!-- <body> omitted: no manuscript (.docx) on file -->
  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
        <mixed-citation>. Kolin DA, Shakur-Still H, Bello A, Chaudhri R, Bates I, Roberts I. Risk factors for blood transfusion in traumatic and postpartum hemorrhage patients: Analysis of the CRASH-2 and WOMAN trials. Plos one. 2020;15(6):e0233274.</mixed-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <mixed-citation>Shahbazi Sighaldeh S, Nazari A, Maasoumi R, Kazemnejad A, Mazari Z. Prevalence, related factors and maternal outcomes of primary postpartum haemorrhage in governmental hospitals in Kabul-Afghanistan. BMC Preg Childb. 2020;20(1):1-9.</mixed-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <mixed-citation>Snelgrove JW. Postpartum haemorrhage in the developing world a review of clinical management strategies. Mcgill J Med. 2009;12(2):61.</mixed-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <mixed-citation>Bahadur A, Khoiwal K, Bhattacharya N, Chaturvedi J, Kumari R. The effect of intrauterine misoprostol on blood loss during caesarean section. J Obstet Gynaecol. 2019;39(6):753-6.</mixed-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <mixed-citation>Janjua M, Imran M. A comparison of the effectiveness of sublingual misoprostol versus intravenous oxytocin infusion in reducing blood loss in first two hours at caesarean section. Pak Postgrad Med J. 2020;31(03):132-7.</mixed-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <mixed-citation>Afkham MS, Hashemnejad M, Saeieh SE, Ataei M, Valizadeh R. Prophylactic effect of rectal and sublingual misoprostol on postpartum hemorrhage in mothers with preeclampsia following cesarean section surgery; a double-blind randomised controlled trial. Ann Med Surg. 2022; <pub-id pub-id-type="doi">10.1016/j.amsu.2022.104175</pub-id>.</mixed-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <mixed-citation>Sel G. Postpartum Bleeding. Practical Guide to Oral Exams in Obstetrics and Gynecology: Springer; 2020. P. 171-5.</mixed-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <mixed-citation>Awoleke JO, Adeyanju BT, Adeniyi A, Aduloju OP, Olofinbiyi BA. Randomised Controlled Trial of Sublingual and Rectal Misoprostol in the Prevention of Primary Postpartum Haemorrhage in a Resource-Limited Community. J Obstet Gynecol India. 2020;70(6):462-70.</mixed-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <mixed-citation>Munawar A, Saeed A, Rehman A. Effect of rectal misoprostol and intravenous ergometrine in patients of postpartum hemorrhage in caesarean section delivery. JSZMC.2018;9(3):1487-89.</mixed-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <mixed-citation>Eftekhari N, Doroodian M, Lashkarizadeh R. The effect of sublingual misoprostol versus intravenous oxytocin in reducing bleeding after caesarean section. J Obstet Gynaecol. 2009;29(7):633-6.</mixed-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <mixed-citation>Sallam HF, Shady NW. Adjunctive sublingual misoprostol for secondary prevention of post-partum hemorrhage during cesarean delivery: double blind placebo randomized controlled trial. Int J Repro Contra Obstet Gynecol. 2018;7(2):496.</mixed-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <mixed-citation>Othman ER, Fayez MF, Abd El Aal DEM, Mohamed HSE-D, Abbas AM, Ali MK. Sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery: a randomized clinical trial. Tai J Obstet Gynecol. 2016;55(6):791-5.</mixed-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <mixed-citation>Abdelaleem AA, Abdelaleem NA, Abbas AM. Intrauterine Misoprostol versus intravenous Oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss: a randomised clinical trial. Int J Repro Contra Obstet Gynecol. 2019;8(4):1663.</mixed-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <mixed-citation>Baig FS, Ali F, Shahid M, Malik A. Comparison of rectally administered misoprostol and oxytocin infusion for management of 3rd stage of labour in 2nd trimester pregnancy loss. Pak Postgrad Med J. 2017;28(2):70-4.</mixed-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <mixed-citation>Eftekhari N, Doroodian M, Lashkarizadeh R. The effect of sublingual misoprostol versus intravenous oxytocin in reducing bleeding after caesarean section. J Obstet Gynaecol. 2009;29(7):633-6.</mixed-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <mixed-citation>Anita MS, Rajoria L, Mehta S. A randomised control study: To evaluate the effect of oxytocin plus misoprostol versus oxytocin or misoprostol alone in reducing blood loss at cesarean section. Int J Clin Obstet Gynaecol. 2018; 2(2): 1-3</mixed-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <mixed-citation>Rasri W. Intrauterine misoprostol plus intravenous oxytocin for reduction of blood loss in cesarean delivery. Thai Journal of Obstetrics and Gynaecology. 2018:237-45.</mixed-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <mixed-citation>Ahmed AO. A comparison of combined rectal misoprostol and oxytocin with oxytocin alone in the control of blood loss during elective caesarean section: a randomised controlled trial. Faculty of obstetrics and gynaecology. Dissertation. 2018.</mixed-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <mixed-citation>Abdullah NS, Homdy BT. Sublingual misoprostol versus oxytocin infusion to reduce blood loss at cesarean section. Dissertation. 2019.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
