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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v4i1.2304</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v4i1.2304</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Obesity and Hypertension among Type-2 Diabetes Mellitus Patients: Analysis of Gender and Age Matched Rural Population of South Punjab, Pakistan</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Ali</surname>
            <given-names>Qazi Masroor</given-names>
          </name>
          <email>masroorqazi@outlook.com</email>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Anjum</surname>
            <given-names>Saba</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Imran</surname>
            <given-names>Ali</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Shafique</surname>
            <given-names>Sadaf</given-names>
          </name>
          <xref ref-type="aff" rid="aff4"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Masroor</surname>
            <given-names>Maria</given-names>
          </name>
          <xref ref-type="aff" rid="aff5"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Aleena Hospital, Bahawalpur</institution>
      </aff>
      <aff id="aff2">
        <institution>Shahida Islam Teaching Hospital, Lodhran</institution>
      </aff>
      <aff id="aff3">
        <institution>Quaid-e-Azam Medical College, Bahawalpur</institution>
      </aff>
      <aff id="aff4">
        <institution>Bahawal Victoria Hospital, Bahawalpur</institution>
      </aff>
      <aff id="aff5">
        <institution>Shaikh Zayed Hospital, Rahim Yar Khan, Pakistan</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Qazi Masroor Ali (masroorqazi@outlook.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2023-02-13">
        <day>13</day>
        <month>02</month>
        <year>2023</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2023</year>
      </pub-date>
      <volume>4</volume>
      <issue>1</issue>
      <fpage>15</fpage>
      <lpage>19</lpage>
      <history>
        <date date-type="received" iso-8601-date="2022-10-25">
          <day>25</day>
          <month>10</month>
          <year>2022</year>
        </date>
        <date date-type="accepted" iso-8601-date="2022-12-16">
          <day>16</day>
          <month>12</month>
          <year>2022</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2023 The Author(s)</copyright-statement>
        <copyright-year>2023</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v4i1.2304" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v4i1.2304.pdf" content-type="application/pdf"/>
      <abstract>
        <sec>
          <title>Objective</title>
          <p>To study the association between obesity and hypertension (HTN) among type-2 diabetes mellitus (T2DM) patients by analyzing age and gender matched rural population of South Punjab, Pakistan.</p>
        </sec>
        <sec>
          <title>Methodology</title>
          <p>This cross-sectional study was conducted at the outpatient department of medicine, Aleena Hospital, Bahawalpur, Pakistan from 1st January 2021 to 30th December 2022. A total of 2538 known patients of T2DM of either gender aged above 18 years with a minimum disease duration of 6 months. All patients had rural residential status. For each male or female patient, gender and age was matched in the next coming patients so that we had equal number of male and female patients corresponding to very similar age. The prevalence of HTN was noted. For Body mass index (BMI) labeling, Asian criteria was used as normal if BMI below 23 kg/m2, overweight if ≥23 kg/m2 and obese if ≥25 kg/m2.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>The mean age and BMI were 50.55±11.75 years and 26.20±5.48 kg/m2 respectively. There were 703 (27.7%) patients who had normal BMI whereas 387 (15.2%) and 1448 (57.1%) were overweight and obese respectively. Hypertension was noted among 1069 (42.1%) patients. Hypertension was noted to have significant association with female gender (p</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>In rural population, female gender had significant association with hypertension, overweight and obesity. Increasing age and duration of diabetes were significantly linked with hypertension and higher BMI.</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Body mass index</kwd>
        <kwd>diabetes mellitus</kwd>
        <kwd>hypertension</kwd>
        <kwd>obesity</kwd>
        <kwd>overweight.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
        <mixed-citation>OMS. Informe Sobre La SituacioÂn Mundial de las enfermedades no transmisibles 2014. Available From: [http://apps.who.int/iris/bitstream/10665/149296/1/WHO_NMH_NVI_15.1_spa.pdf?ua=1&amp;ua=1.]</mixed-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <mixed-citation>International Diabetes Federation. Members. [Updated 2022, cited 2022] Available from: [https://idf.org/our-network/regions-members/middle-east-and-north-africa/members/43-pakistan.html]</mixed-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <mixed-citation>Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217-23.</mixed-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <mixed-citation>Patel SA, Ali MK, Alam D, Yan LL, Levitt NS, Antonio B, et al. Obesity and its Relation With Diabetes and Hypertension: A Cross-Sectional Study Across 4 Geographical Regions. Glob Heart. 2016;11(1):71-9.</mixed-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <mixed-citation>Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377(9765):557-67.</mixed-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <mixed-citation>Aamir AH, Ul-Haq Z, Fazid S, Shah BH, Raza A, Jawa A, et al. Type 2 diabetes prevalence in Pakistan: what is driving this? Clues from subgroup analysis of normal weight individuals in diabetes prevalence survey of Pakistan. Cardiovasc Endocrinol Metab. 2020;9(4):159-64.</mixed-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <mixed-citation>Ali QM , AkramM, Imran A, Shafique S, Ullah HMK, Khan R, Masroor M, Chaudhary GM. Factors associated with poor glycemic control: A real world data from a private outpatient clinic of South Punjab, Pakistan. J Pak Soc Intern Med. 2022;3(3):210-5.</mixed-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <mixed-citation>Chaudhary GMD, Tameez Ud Din A, Chaudhary FMD, Tanveer A, Siddiqui KH, Asma TU, et al. Association of Obesity Indicators with Hypertension in Type 2 Diabetes Mellitus Patients. Cureus. 2019;11(7):e5050.</mixed-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <mixed-citation>Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JP, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors. Postgrad Med J. 2006;82(966):280-84.</mixed-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <mixed-citation>Whitmore C. Type 2 diabetes and obesity in adults. Br J Nurs. 2010;19(14):880-86.</mixed-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <mixed-citation>Thomas MC, Zimmet P, Shaw JE. Identification of obesity in patients with type 2 diabetes from Australian primary care: the NEFRON-5 study. Diabetes Care. 2006;29(12):2723-5.</mixed-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <mixed-citation>Damian DJ, Kimaro K, Mselle G, Kaaya R, Lyaruu I. Prevalence of overweight and obesity among type 2 diabetic patients attending diabetes clinics in northern Tanzania. BMC Res Notes. 2017;10(1):515.</mixed-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <mixed-citation>Gezawa ID, Uloko AE, Gwaram BA, Ibrahim DA, Ugwu ET, Mohammed IY. Pattern of Obesity Among Patients with Type 2 Diabetes at a Tertiary Healthcare Center in Northern Nigeria. Diabetes Metab Syndr Obes. 2019;12(10):2785-90.</mixed-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <mixed-citation>Fadupin GT, Joseph EU, Keshinro OO. Prevalence of obesity among type 2 diabetics in Nigeria a case study of patients in Ibadan, Oyo state, Nigeria. Afr J Med Med Sci 2004;33(2):381–4.</mixed-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <mixed-citation>Abed BB. Prevalence of obesity among type 2 diabetic patients: non-smokers housewives are the most affected in Jeddah, Saudi Arabia. Open J Endocr Metab Dis 2013;03(1):25–30.</mixed-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <mixed-citation>Kiros KG, Abyu GY, Belay DS, Goyteom MH, Welegebriel TK. Magnitude of overweight and associated factors among type 2 diabetes mellitus patients at Mekelle public hospitals, Tigray, Ethiopia: a cross-sectional study. BMC Res Notes. 2019;12(1):762.</mixed-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <mixed-citation>Ali YA, Almobarak AO, Awadalla H, Elmadhoun WM, Ahmed MH. Obesity among Sudanese adults with diabetes: a population-based survey. Ann Transl Med. 2017;5(12):252.</mixed-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <mixed-citation>Naseri MW, Esmat HA, Bahee MD. Prevalence of hypertension in Type-2 diabetes mellitus. Ann Med Surg (Lond). 2022;78(1):103758.</mixed-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <mixed-citation>Li M, Wang Y, Liu Z, Tang X, Mu P, Tan Y, et al. Females with type 2 diabetes mellitus are prone to diabetic retinopathy: A twelve-province cross-sectional study in China. J Diabetes Res. 2020;<pub-id pub-id-type="doi">10.1155/2020/5814296</pub-id></mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
