Cannabis is among the most commonly used psychoactive substance in the world1. Smoking Cannabis is common in the cultural events of Sub-Continent and some visitors smoke it over shrines during the festivals. A 37- years old male, married, driver by profession, the only earner of his family with three dependents, presented in emergency department (ED) in January 2022 with severe, diffuse, thunderclap and non-resolving headache for the last two days. He used oral diclofenac sodium for one day without medical advice and there was no improvement in the headache. He was a smoker and also smoked cannabis during last one month and smoked cannabis in amounts more than his usual routine. On examination, his blood complete picture showed TLC 11.7 ×10³/cubic millimeter (cmm), Hb.15.3 gm/dl, PLT 180 × 10³ / cmm, total bilirubin 1.2 mg/dl,ALP260 U/L,ALT39 U/L, Urea 36 mg/dl, Creatinine 0.8 mg/dl and erythrocyte sedimentation rate was 30 mm in 1st hour. He was treated with Enoxaparin, Tramadol and Metoclopramide. Naproxen Sodium and Normal Saline were given on day one only. Patient significantly improved after 5 days of treatment and was discharged on direct oral anticoagulants.