JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v4i4.2357 jpsim.v4i4.2357 Original Research Mean Platelet Volume as a Predictor of Severity of Acute Ischaemic Stroke Using Modified Rankin Score Butt Nasir Farooq Rathore Rabia Latif Hina hinalatif2011@gmail.com * Heba-Tul-Noor Mehmood Hassan Randhawa Fawad Ahmad Department of Medicine, King Edward Medical University, Lahore *Correspondence: Hina Latif (hinalatif2011@gmail.com) 29 11 2023 2023 4 4 284 288 30 07 2023 17 08 2023 Copyright © 2023 The Author(s) 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To determine the association of mean platelet volume in terms of predictor of severity of acute ischemic stroke using Modified Rankin Score (MRS).

 Methodology

From July 2019 to June 2021, this observational study was carried out at the Mayo Hospital Lahore's Departments of Medicine and Emergency. 225 patients in total were chosen utilizing the non-probability convenient sampling technique. Patients were divided into 2 groups according to their MRS scores (Group A: score 0 to 2, Group B: score 3 or higher). Blood samples were taken in order to test MPV. The MRS was used to determine the severity of an ischemic stroke.

 Results

Out of 225 patients, 108 were assigned to Group A (MRS 0–2) and 117 to Group B (MRS 3 or higher). The mean±SD of MPV in Group B was 8.55 0.67, while it was 8.37 0.65 in Group A, which was statistically noteworthy (p=0.004). The effect of MPV on ischemic stroke was still statistically significant (OR: 1.579, p=0.3) after risk profiles linked to ischemic stroke were taken into account in the multivariate logistic regression model. The MPV had a significant discriminative value for predicting severe ischemic stroke based on MRS ≥ 3 from a mild stroke incidence (MRS < 3), as evidenced by the area under the ROC curve of 0.592 (95% CI: 0.43-0.6).

 Conclusion

Mean Platelet volume can be a useful preliminary indicator which can be utilized in primary acute ischemic stroke patients as a marker of severity using Modified Rankin Score.

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