JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v4i4.2360 jpsim.v4i4.2360 Original Research Prevalence of in Hospital Acute Kidney Injury in Patients Having Admission Hyperuricemia Khan Zuhra Naheed zuhra_khan17@yahoo.com * Saeed Saad Muhammad Qureshi Sameed Ullah Senior Registrar, Pakistan Kidney and liver institute, Lahore Senior Instructor Medicine and Gastroenterology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore Senior Medical Officer, Northwest General Hospital, Peshawar, Pakistan *Correspondence: Zuhra Naheed Khan (zuhra_khan17@yahoo.com) 29 11 2023 2023 4 4 297 301 17 08 2023 12 08 2023 Copyright © 2023 The Author(s) 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To determine the prevalence of acute kidney injury among patients admitted to tertiary-care hospital with hyperuricemia, secondary to any cause.

 Methodology

This descriptive study was conducted in a tertiary-care hospital from January, 2022 to June, 2023. A total of 118 patients were selected by using non-probabilistic consecutive sampling. Patients having admission serum uric acid levels ≥ 7 mg/dl were labeled as having admission-hyperuricemia. Patients developing AKI during hospital stay were diagnosed using KDIGO guidelines as after-mentioned.

 Results

The prevalence of AKI in patients having hyperuricemia at the time of admission to our hospital was recorded in 25.42%(n=30) whereas 74.58%(n=88) had no findings of AKI.

 Conclusion

It has been shown that there is a greater risk of developing AKI in patients who have hyperuricemia upon admission. Nevertheless, it is essential to do multicenter trials in order to authenticate our findings.

 Keywords Acute kidney injury hyperuricemia serum uric acid level serum creatinine References Vargas-Santos AB, Neogi T. Management of gout and hyperuricemia in CKD. American J Kidney Dis. 2017;70(3):422-39. Billiet L, Doaty S, Katz JD, Velasquez MT. Review of hyperuricemia as new marker for metabolic syndrome. Int Scholarly Res Notices. 2014; 10.1155/2014/852954. Liu Z, Chen T, Niu H, Ren W, Li X, Cui L, et al. The establishment and characteristics of rat model of atherosclerosis induced by hyperuricemia. Stem Cells Int. 2016; 10.1155/2016/1365257 . Cao J, Wang C, Zhang G, Ji X, Liu Y, Sun X, et al. Incidence and simple prediction model of Hyperuricemia for urban Han Chinese adults: a prospective cohort study. Int J Environmentl Res Public Health. 2017;14(1):67. Zuk A, Bonventre JV. Acute kidney injury. Annual Rev Med. 2016;67(2):293-307. Sprigings DC, Chambers JB. Acute medicine: a practical guide to the management of medical emergencies: John Wiley & Sons; 2017. Patel MP, Kute VB, Patel HV, Shah PR, Trivedi HL, Vanikar AV. Severe hyperuricemia with acute kidney injury: vigilance needed for spontaneous tumor lysis syndrome. Clinical Queries: Nephrol. 2015;4(3-4):41-3. Cheungpasitporn W, Thongprayoon C, Harrison AM, Erickson SB. Admission hyperuricemia increases the risk of acute kidney injury in hospitalized patients. Clin Kid J. 2016;9(1):51-6. Susic D, Frohlich ED. Hyperuricemia: a biomarker of renal hemodynamic impairment. Cardiorenal Med. 2015;5(3):175-82. Li L, Yang C, Zhao Y, Zeng X, Liu F, Fu P. Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies. BMC Nephrol. 2014;15:1-12. Feig DI. Uric acid-a novel mediator and marker of risk in chronic kidney disease? Cur Opinion Nephrol Hyperten. 2009;18(6):526. Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, et al. Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009;20(1):223. Pannu N, James M, Hemmelgarn BR, Dong J, Tonelli M, Klarenbach S, et al. Modification of outcomes after acute kidney injury by the presence of CKD. Am J Kidney Dis. 2011;58(2):206-13. Okura T, Higaki J, Kurata M, Irita J, Miyoshi K-i, Yamazaki T, et al. Elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis subanalysis of the Japanese Coronary Artery Disease (JCAD) study. Circulation J. 2009;73(5):885-91. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta‐analysis. Arthri Care Res: Official J Am Coll Rheumatol. 2010;62(2):170-80. Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, et al. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol. 2011;22(9):1748. Tehrani S, Laing C, Yellon DM, Hausenloy DJ. Contrast‐induced acute kidney injury following PCI. Eu J Clin Invest. 2013;43(5):483-90. Hu J, Chen R, Liu S, Yu X, Zou J, Ding X. Global incidence and outcomes of adult patients with acute kidney injury after cardiac surgery: a systematic review and meta-analysis. J Cardiothor Vasc Anesth. 2016;30(1):82-9. Roncal CA, Mu W, Croker B, Reungjui S, Ouyang X, Tabah-Fisch I, et al. Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am J Physiol-Renal Physiol. 2007;292(1):F116-F22. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67(5):1739-42. Yu M-A, Sánchez-Lozada LG, Johnson RJ, Kang D-H. Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hyperten. 2010;28(6):1234-42. Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A, Group NM-aI. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;54(6):1012-24. Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210-21. Zhou Y, Fang L, Jiang L, Wen P, Cao H, He W, et al. Uric acid induces renal inflammation via activating tubular NF-κB signaling pathway. PloS one. 2012;7(6):e39738. Netea MG, Kullberg BJ, Blok WL, Netea RT, WM Van der Meer J. The role of hyperuricemia in the increased cytokine production after lipopolysaccharide challenge in neutropenic mice. Blood J Am Soc Hematol. 1997;89(2):577-82. Kang D-H, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002;13(12):2888-97.