JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v5i1.2406 jpsim.v5i1.2406 Original Research Effect of Nebulized Magnesium Sulphate in Terms of the In-Hospital Outcome of Patients Admitted with Acute Exacerbation of Chronic Obstructive Pulmonary disease Ain Qurratul qurratulain92@hotmail.com * Randhawa Fawad Ahmad Butt Nasir Farooq Aslam Ayesha Latif Hina Rathore Rabia Central Park Medical College, Lahore King Edward Medical University, Lahore *Correspondence: Qurratul Ain (qurratulain92@hotmail.com) 28 02 2024 2024 5 1 383 387 07 10 2023 11 12 2023 Copyright © 2024 The Author(s) 2024 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To evaluate the efficacy of Magnesium Sulphate (MgSO4) with the conventional treatment in acute exacerbation chronic obstructive pulmonary disease (AECOPD)

 Methodology

This Quasi-experimental study was conducted in Department of Internal Medicine from July 2020 to July 2022. The study involved 160 patients in total. There were two groups of patients. Group A was nebulized with 250mg of MgSO4 four times a day along with conventional treatment. Group B was given only conventional treatment. Conventional treatment included oxygen inhalation, anti-cholinergic and beta-2 agonist nebulization, intravenous steroids, and intravenous antibiotics. Both groups were followed for five days to assess the effect of nebulized magnesium.

 Results

Group A required assisted ventilation for 2–3 days for 28% of the subjects (22 patients out of 80), while group B required it for 81% of the subjects (65 patients out of 80). In addition, only 9% of patients in group A and 8% of patients in group B needed assisted ventilation for four to five days. In comparison to group A, which had 33% of patients discharged on the fourth day and 20% on the fifth day or later, group B saw 53% of patients discharged on the fourth day and 20% on the fifth day or later. The results showed that PCO2 and peak expiratory flow rate (PEFR) have a significant variance between group A and group B and values have no significant variance between group A and group B on the first day and the last day.

 Conclusion

Nebulized supplementation improves in-hospital outcomes in patients presenting with acute exacerbation of COPD as compared to the patients not receiving nebulized magnesium sulphate.

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