JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v5i1.2410 jpsim.v5i1.2410 Original Research Lactate Dehydrogenase as a Predictor of Disease Severity in Coronavirus Disease (Covid-19) Komal Tayyeba drtksami@gmail.com * Mumtaz Sami Ullah Rafique Sana Ali Akhtar Iqtadar Somia Haque Israr Ul King Edward Medical University, Mayo hospital, Lahore Shalamar Medical and Dental College, Shalamar Hospital, Lahore *Correspondence: Tayyeba Komal (drtksami@gmail.com) 28 02 2024 2024 5 1 404 406 12 10 2023 16 12 2023 Copyright © 2024 The Author(s) 2024 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To find out association between serum lactate dehydrogenase levels and coronavirus disease severity.

 Methodology

It was a cross sectional study done at mayo hospital Lahore for six months.100 patients of age 15-80 years of either gender having COVID-19 PCR positive were included. Serum LDH levels were sent at the time of admission, day 7 & day 14 to the pathology laboratory KEMU.To assess clinical severity of coronavirus disease, all the enrolled patients were categorized as mild, moderate, severe & critical cases on the basis of oxygen/mechanical ventilation requirement .Data was analyzed using SPSS-26.

 Results

A very strong positive correlation observed between serum LDH level a severity of corona virus disease i.e. r = 0.906, p-value < 0.00001. LDH showed Sensitivity 59.52%, Positive Predictive Value 30.12% and Diagnostic Accuracy 25%.

 Conclusion

LDH is a strong predictor of COVID-19 disease severity. Thereforein future LDH can be used to see disease severity.

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