JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v5i2.2426 jpsim.v5i2.2426 Original Research Frequency of Myopathy in Cases of Diabetes Mellitus Using Atorvastatin Qaisar Wafa wafa.qaisar04@gmail.com * Khan Imran Imran Muhammad Khan Fahad Aman Rauf Hafiz Abdul Shafi Nazish Al Aleem Medical College, Gulab Devi Hospital Lahore *Correspondence: Wafa Qaisar (wafa.qaisar04@gmail.com) 07 06 2024 2024 5 2 484 487 07 02 2024 13 04 2024 Copyright © 2024 The Author(s) 2024 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

The prime objective of this study was to determine the frequency of myopathy in diabetes mellitus patients

using atorvastatin.

 Methodology

This cross-sectional study was conducted in the department of medicine at Gulab Devi Hospital, Lahore, after

the approval of ethical committee and informed consent of the participants. Sample of 107 diabetic patients of both

genders, aged between 20-70 years were included through non-probability consecutive sampling method.

Electromyography was performed on selected participants and their serum creatinine kinase (CK) levels were assessed.

Data analysis was done through SPSS version 16.

 Results

The mean age in this study was 51±10.8 years. Majority of the patients were male 59(55%) while female were

48(44.9%). Mean duration elapsed from diagnosis of diabetes was 9.42±2.15 years. It was observed that patients were on

statin therapy from last 6.26±1.46 months. Myopathy was present in the 66(61%) cases while 41(38.3%) did not have this

condition.

 Conclusion

The study concluded that symptoms of myopathy are highly prevalent in diabetic patients on statin therapy

and the frequency of myopathy rises with the atorvastatin dosage. The study provides valuable insights into the potential

musculoskeletal side effects of statin therapy in this specific patient population.

 Keywords Statin Diabetes Mellitus Myopathy Creatinine Kinase Electromyography