<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.3 20210610//EN" "JATS-archivearticle1-3.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v5i3.2449</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v5i3.2449</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Knowledge and Attitude Towards Decompensated Liver Disease Patients Assessment Amongst Health Care Providers of a Tertiary Care Hospital- A Cross Sectional Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Saeed</surname>
            <given-names>Bilal</given-names>
          </name>
          <email>ayubian2019@gmail.com</email>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Hayat</surname>
            <given-names>Arshad</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Asghar</surname>
            <given-names>Asma</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ashfaq</surname>
            <given-names>Usama</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Anwar</surname>
            <given-names>Wasif</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Izhar</surname>
            <given-names>Sana</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Combined Military Hospital Peshawar</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Bilal Saeed (ayubian2019@gmail.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2024-08-30">
        <day>30</day>
        <month>08</month>
        <year>2024</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2024</year>
      </pub-date>
      <volume>5</volume>
      <issue>3</issue>
      <fpage>605</fpage>
      <lpage>608</lpage>
      <history>
        <date date-type="received" iso-8601-date="2024-03-04">
          <day>04</day>
          <month>03</month>
          <year>2024</year>
        </date>
        <date date-type="accepted" iso-8601-date="2024-08-07">
          <day>07</day>
          <month>08</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2024 The Author(s)</copyright-statement>
        <copyright-year>2024</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v5i3.2449" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v5i3.2449.pdf" content-type="application/pdf"/>
      <abstract>
        <sec>
          <title>Objective</title>
          <p>To assess the knowledge and attitude of healthcare workers towards assessment of decompensated liver disease patients.</p>
        </sec>
        <sec>
          <title>Methodology</title>
          <p>This cross-sectional observational study was conducted in the Department of Gastroenterology, Combined Military Hospital Peshawar from September 2023 to November 2023. Non-probability consecutive sampling technique was used and included. All the patient’s fulfilling inclusion and exclusion criteria were observed during the study period. A preformed excel sheet was used to collect data including age, gender, education level, occupation, duration of illness, duration of treatment, etiology, medications. Patients of both genders from ages 18-84 years with known decompensated chronic liver disease admitted indoor or visited outpatient department during the study period. Frequency and percentages were calculated for quantitative variables and mean ± SD. P-value of &lt; 0.05 was considered statistically significant.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>Mean age of the patients was 53.16 (± 12.70) years. Out of 95 patients, 30 (32.70%) were females while 65 (67.30%) were males. Mean duration of Chronic Liver Disease was 5.15 (± 1.85) months. Child Pugh scoring was performed for 26 (27.40%) patients only. 29(90%) of the doctors had knowledge of assessing DCLD patients by using Child Pugh score, 5(15%) were used to calculate CPT score while assessing DCLD patients. Regarding medication, 78% were prescribing inappropriate drugs without any assessment and indications of drugs i.e. rifixamine, beta blockers, proton pump inhibitors, lactulose, antibiotics, ulsanic acid, furosemide, and spironolactone. Frequency of more than 5 drugs prescription was 80%.</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>Careful assessment and managing decompensated liver disease patients not only slows down the disease progression but can also decrease morbidity and mortality related to decompensated liver disease.</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Attitude</kwd>
        <kwd>knowledge</kwd>
        <kwd>liver disease</kwd>
        <kwd>health care workers</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <!-- <body> omitted: no manuscript (.docx) on file -->
  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
        <mixed-citation>Harshad Devarbhavi, Sumeet K. Asrani, Juan Pablo Arab, Yvonne Ayerki Nartey, Elisa Pose, Patrick S. Kamath,Global burden of liver disease. J Hepatol. 2023;79(2):516-37.</mixed-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <mixed-citation>Pakistan tackles high rates of hepatitis from many angles. [Updated July 11, 2017] Available from: [https://www.who.int/news-room/feature-stories/detail/pakistan-tackles-high-rates-of-hepatitis-from-many-angles]</mixed-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <mixed-citation>Sharma B, John S. Hepatic Cirrhosis. [Updated 2022 Oct 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan</mixed-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <mixed-citation>Raja AM, Ciociola E, Ahmad IN, Dar FS, Naqvi SMS, Moaeen-Ud-Din M, Kaukab Raja G, Romeo S, Mancina RM. Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan. Int J Mol Sci. 2020;21(10):3558.</mixed-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <mixed-citation>Qureshi H, Bile KM, Jooma R, Alam SE, Afridi HU. Prevalence of hepatitis B and C viral infections in Pakistan: findings of a national survey appealing for effective prevention and control measures. East Mediterr Health J. 2010;16 (Suppl):S15-23.</mixed-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <mixed-citation>Tsoris A, Marlar CA. Use Of The Child Pugh Score In Liver Disease. [Updated 2023 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: [https://www.ncbi.nlm.nih.gov/books/NBK542308]</mixed-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <mixed-citation>Buechter M, Gerken G. Liver Function-How to Screen and to Diagnose: Insights from Personal Experiences, Controlled Clinical Studies and Future Perspectives. J Pers Med. 2022;12(10):1657.</mixed-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <mixed-citation>Cirrhosis: common medication for management of liver diseases. Available from: [www.nbt.nhs.uk/our-services/a-z-services/gastroenterology-hepatology/gastroenterology-hepatology-patient-information/cirrhosis]</mixed-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <mixed-citation>Perez IC, Bolte FJ, Bigelow W, Dickson Z, Shah NL. Step by Step: Managing the Complications of Cirrhosis. Hepat Med Evid Res. 2021;13(5):45-57.</mixed-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <mixed-citation>Javed N, Nadeem MH, Ghazanfar H. Hepatitis B and C in Pakistan: A community survey. Cureus. 2019;11(10):e5992.</mixed-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <mixed-citation>Zahoor S, Khan A, Asif S, Tabraiz SA, Mustafa H, Ansar S, Hanif S, Raza HA. Past and Future Perspectives for Hepatitis B and C in Pakistan. Cureus. 2021;13(8):e17521.</mixed-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <mixed-citation>Tsoris A, Marlar CA. Use of The Child Pugh Score In Liver Disease. [Updated 2023 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023</mixed-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <mixed-citation>Palmieri C, Macpherson IR. A review of the evidence base for utilizing Child-Pugh criteria for guiding dosing of anticancer drugs in patients with cancer and liver impairment. ESMO Open. 2021;6(3):100162.</mixed-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <mixed-citation>Hayward KL, Weersink RA. Improving Medication-Related Outcomes in Chronic Liver Disease. Hepatol Commun. 2020;4(11):1562-77.</mixed-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <mixed-citation>Weersink RA, Bouma M, Burger DM, Drenth JP, Harkes-Idzinga SF, Hunfeld NG, Metselaar HJ, Monster-Simons MH, Taxis K, Borgsteede SD. Evidence-based recommendations to improve the safe use of drugs in patients with liver cirrhosis. Drug Safety. 2018;41(6):603-13.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
