JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v5i4.2465 jpsim.v5i4.2465 Original Research Diagnostic Accuracy of L-FABP-to-Creatinine Ratio (LCR) for Prediction of Kidney Damage in Type-2 DM Patients Taking Albumin-to-Creatinine Ratio (ACR) as Gold Standard Sultan Eesha Sultan Aqib Dar Rehma Sultan Ushna Ghani Muhammad Haris Kousar Naheeda drnaheedapgmi@gmail.com * Garrison Medical Center, Jarrar Camp Rawalpindi Shaukat Khanum Memorial Cancer Hospital Lahore, Services Institute of Medical Sciences Lahore LRBT Hospital Township Lahore Punjab Institute of Cardiology Lahore PGMI Lahore *Correspondence: Naheeda Kousar (drnaheedapgmi@gmail.com) 09 12 2024 2024 5 4 690 693 02 07 2024 14 11 2024 Copyright © 2024 The Author(s) 2024 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To determine the diagnostic accuracy of LCR for the prediction of kidney damage in Type-2 Diabetes Mellitus

patients keeping ACR as gold standard.

 Methodology

It was a descriptive study conducted in diabetic center of Lahore General Hospital on 70 Type 2 diabetics, 35 to

55 years old having negative spot urine dipstick test for albumin. After informed consent, urine samples were collected for

measurements of ACR and LCR. Patients with cardiovascular disease, hypertension, liver disease, pregnancy, anemia or

any other chronic disease were excluded. ACR 30-300 mg/g was labeled as having Diabetic Nephropathy (DN). Data was

analyzed in SPSS-27.

 Results

The mean ± SD age, BMI, duration of DM of participants was 49.6 ± 4.7 years, 29.3 ± 3.0 kg/m2, 6.2 ± 1 years

respectively. Using 5.5 µg/g cut off value for LCR, the sensitivity, specificity, positive predictive value, negative

predictive value, Youden's index and overall diagnostic accuracy was 85.5%, 93.3%, 0.98, 0.6, 0.78 and 0.87 respectively.

Area under curve (AUC) was 0.81.

 Conclusion

L-FABP has overall good diagnostic accuracy to predict kidney damage in Type-2 diabetics.

 Keywords Albumin Creatinine Liver type FattyAcid Binding Protein Creatinine Type 2 DM Kidney damage Ethics Statement

Ethics committee: Ethical Review Committee, University of Health Sciences, Lahore, Pakistan. Approval number: UHS/Education/126-22/8049, dated 02-11-2022.

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