JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v5i4.2473 jpsim.v5i4.2473 Original Research Serum Uric Acid as a Predictor of Perinatal Outcome in Women with Pre-eclampsia: A prospective Cohort Study Mujeeb Anum Tabassum Hina Masoud Atikka Ahmed Madiha vazim4847@gmail.com * Bokhari Nadia Ahmed Fatima Ambreen Fauji Foundation Hospital, Rawalpindi-Pakistan *Correspondence: Madiha Ahmed (vazim4847@gmail.com) 09 12 2024 2024 5 4 723 728 16 02 2024 02 11 2024 Copyright © 2024 The Author(s) 2024 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives

To assess the connotation among elevated serum uric acid (SUA) levels and adverse fetal outcomes in women with pre-eclampsia.

 Methodology

This Prospective, cohort study was conducted in the Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Rawalpindi. Ethical approval was granted by the ERC of the hospital. A total of 60 women (30 exposed and 30 unexposed) with of age 18-40 years were included. Patients with already taking medications for hyperuricemia, chronic hypertension, CRF and severe systemic illness like 2 uncontrolled diabetes mellitus, heart diseases were excluded. Group A (exposed) included the females with serum uric acid levels ≥6 mg/dl on presentation while Group B (unexposed) included pregnant females with serum uric acid levels. Data was analyzed using SPSS-25.0

 Results

The study results indicated that 50.0% of women with serum uric acid level of ≥6 mg/dl and pre-eclampsia experienced low birth weight, whereas only 26.67% of women having a SUA level of

 Conclusion

This study concluded that there is a positive association between high serum uric acid levels and adverse feto-maternal outcome.

 Keywords Preeclampsia Uric acid Feto-maternal outcome Ethics Statement

Ethics committee: Ethics Committee, Fauji Foundation Hospital, Rawalpindi, Pakistan. Approval number: 415/FFH/RWP, dated 07-09-2024.

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