JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i1.2504 jpsim.v6i1.2504 Original Research Study of Platelet to Lymphocyte Ratio as a Predictor Inflammatory Marker for Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus Noor Heba Tul hebatulnoor@gmail.com * Butt Nasir Farooq Latif Hina Rathore Rabia Bangash Anam Fatima Iqbal Adil King Edward Medical University/Mayo Hospital Lahore *Correspondence: Heba Tul Noor (hebatulnoor@gmail.com) 10 03 2025 2025 6 1 16 21 17 09 2024 23 01 2025 24 02 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To compare ratio of platelet to lymphocyte (PLR) in diabetic patients with nephropathy to those diabetics without nephropathy.

 Methods

It was an observational study carried out in the medical department from June 2022 to May 2023. A total of 246 patients of type 2 diabetes mellitus hospitalized in all medical wards were included. Based on urinary albumin excretion, two groups of patients were formed: diabetics without nephropathy (Group A) and diabetics with nephropathy (Group B). Ratio of Platelet to lymphocyte was calculated by dividing platelet count with lymphocyte count and ratio of neutrophil to lymphocyte (NLR) was calculated by dividing neutrophil to lymphocyte count. PLR and NLR were compared amongst both groups.

 Results

There were 246 subjects (111 females, 134 males). 131 subjects did not have nephropathy, 115 patients had nephropathy. Comparison of hematological parameters showed that NLR of patients with type 2 DM with nephropathy was 2.59 ± 0.51 and without nephropathy group was 1.70 ± 0.44. The PLR of diabetic nephropathy group was 251 ± 62.4 and that without nephropathy was 213 ± 59.6. Statistical significance (p < 0.05) was seen in the NLR and PLR values of the two groups when compared using the student t-test.

 Conclusion

Increased ratio of platelet-to-lymphocyte significantly correlates with diabetic nephropathy, and may serve as a predictor inflammatory marker for diabetic nephropathy.

 Keywords Diabetic Nephropathy platelet-to-lymphocyte ratio type 2 Diabetes mellitus Ethics Statement

Ethics committee: Institutional Review Board, King Edward Medical University, Lahore, Pakistan. Approval number: 343/RC/KEMU, dated 22-02-2022.

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