JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i1.2507 jpsim.v6i1.2507 Original Research Effect of Increased Portal Vein Diameter on Portal Vein Thrombosis in Decompensated Chronic Liver Disease Raffad raffadraffad41371@import.invalid * Malik Kafayat-Ullah Kamal Asma Kamal Asifa Ain Qurat-ul Iqbal Iram 1Services Institute of Medical Science Lahore General Hospital *Correspondence: Raffad (raffadraffad41371@import.invalid) 10 03 2025 2025 6 1 32 37 19 10 2024 16 01 2025 22 02 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

To determine the association between portal vein diameter and portal vein thrombosis in patients with decompensated chronic liver disease.

 Methodology

This case-control study was conducted at the Department of Medicine, Lahore General Hospital, Lahore, involving 84 patients with decompensated chronic liver disease observed over six months. Of these, 42 patients who developed portal vein thrombosis were categorized as cases, while the remaining 42 served as controls. Portal vein diameter was measured using ultrasonography, and chi-square analysis was used to test the association between portal vein diameter and portal vein thrombosis. Statistical analysis was performed using SPSS version 17.0.

 Results

Among the 84 patients, 32 (38%) were female, and 52 (62%) were male. The average age was 54.4 ± 2.2 years. Portal vein diameter greater than 13 mm was observed in 20 (24%) patients. No significant association was found between portal vein diameter and portal vein thrombosis (p-value = 0.306).

 Conclusion

Portal vein diameter is not associated with portal vein thrombosis in patients with decompensated chronic liver disease. Larger, multicenter studies are needed to validate these findings and identify preventive measures.

 Keywords Portal Vein Thrombosis Liver Cirrhosis Portal Vein Diameter Child Pugh's Ethics Statement

Ethics committee: Institutional Review Board / Ethics Committee (IRB/EC). Approval number: 457/24/PGMI.

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