<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.3 20210610//EN" "JATS-archivearticle1-3.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v6i1.2513</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v6i1.2513</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Research</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Ureteroscopy Under General Anesthesia Versus Spinal Anesthesia: Stone Clearance and Morbidity</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Butt</surname>
            <given-names>Imran Masood</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Iqbal</surname>
            <given-names>Umar</given-names>
          </name>
          <email>umer8808@gmail.com</email>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Saqib</surname>
            <given-names>Muhammad</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Khan</surname>
            <given-names>Muhammad Aslam</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Ali</surname>
            <given-names>Mudassar</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Sheikh</surname>
            <given-names>Fareeha</given-names>
          </name>
          <xref ref-type="aff" rid="aff4"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Rashid Latif Medical College Lahore</institution>
      </aff>
      <aff id="aff2">
        <institution>Punjab Institute of Neurosciences Lahore</institution>
      </aff>
      <aff id="aff3">
        <institution>Children Hospital Lahore</institution>
      </aff>
      <aff id="aff4">
        <institution>Allama Iqbal Medical College Lahore</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Umar Iqbal (umer8808@gmail.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2025-03-10">
        <day>10</day>
        <month>03</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2025</year>
      </pub-date>
      <volume>6</volume>
      <issue>1</issue>
      <fpage>60</fpage>
      <lpage>64</lpage>
      <history>
        <date date-type="received" iso-8601-date="2024-04-15">
          <day>15</day>
          <month>04</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd" iso-8601-date="2025-01-22">
          <day>22</day>
          <month>01</month>
          <year>2025</year>
        </date>
        <date date-type="accepted" iso-8601-date="2025-02-22">
          <day>22</day>
          <month>02</month>
          <year>2025</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2025 The Author(s)</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v6i1.2513" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v6i1.2513.pdf" content-type="application/pdf"/>
      <abstract>
        <sec>
          <title>Objective</title>
          <p>This study aims to compare and contrast ureteroscopy procedures performed under spinal anesthesia and general anesthesia, focusing on complications, stone clearance rates, and relevant variables.</p>
        </sec>
        <sec>
          <title>Methodology</title>
          <p>The study was conducted at the Kidney Centre, Women's University of Dera Ismail Khan, from January 2021 to January 2022, focusing on urinary calculus disease. A total of 100 patients aged 18 to 50 underwent ureteroscopic procedures for the treatment of ureteric stones, with 69 males and 31 females. The patients were divided into two groups: Group A received general anesthesia, and Group B underwent spinal anesthesia. Comprehensive data, including demographics, stone characteristics, operative time, hospital stay, and complications, were collected and analyzed using statistical methods.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>Group B, with spinal anesthesia, exhibited a significantly shorter operative time (31.5 ± 2.15 minutes) compared to Group A under general anesthesia (41.5 ± 1.30 minutes, p=0.033). Group B also showed a trend towards shorter hospital stay (18.2 ± 6.9 hours) compared to Group A (22.6 ± 8.1 hours, p=0.073). Postoperative complications, such as pain, fever, and analgesia requirement, were comparable between the two groups.</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>The study suggests that general anesthesia may be superior to spinal anesthesia for ureteroscopy in terms of safety and stone clearance rates, while spinal anesthesia is associated with a lower risk of complications. The findings underscore the effectiveness of ureteroscopy in treating lower ureteric stones and highlight the adaptability of anesthesia choices to individual patient needs.</p>
        </sec>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Ureteroscopy</kwd>
        <kwd>General anesthesia</kwd>
        <kwd>Spinal anesthesia</kwd>
        <kwd>Ureteric stones</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <!-- <body> omitted: no manuscript (.docx) on file -->
  <back>
    <notes notes-type="ethics-statement">
      <title>Ethics Statement</title>
      <p>Ethics committee: Institutional Review Board / Ethics Committee (IRB/EC). Approval number: IRB/2020/024, dated 23-12-2020.</p>
    </notes>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
        <mixed-citation>Channa AA, Ashfaq S, Ahmad MZ, Asif M, Shahid MW, Ahmed N. Ureteroscopy under General Anesthesia Versus Spinal Anesthesia: Stone Clearance and Morbidity. Pak J Med Health Sci. 2022;16(04):624-.</mixed-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <mixed-citation>Cai H, Wu X, Chen X, Chen W. Comparison of the effects of general, spinal and epidural anesthesia on ureter access and surgical outcomes during flexible ureterorenoscopy for transurethral single stone removal surgeries: a monocentric retrospective study. Ann Med. 2021;53(1):2110-9.</mixed-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <mixed-citation>Oztekin U, Caniklioglu M, Atac F, Kantekin CU, Gurel A, Isikay L. Comparison of safety and efficiency of general, spinal and epidural anesthesia methods used for the endoscopic surgical treatment of ureteral stones: which one is better to access the ureter and reach the stone?. Urol J. 2020 May 1;17(3):237.</mixed-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <mixed-citation>Sahan M, Sarilar O, Akbulut MF, Demir E, Savun M, Sen O. Flexible ureterorenoscopy and laser lithotripsy with regional anesthesia vs general anesthesia: A prospective randomized study. Int Braz J Urol. 2020;46(9):1010-8.</mixed-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <mixed-citation>Uludağ Ö, Yücel MÖ, Kuşderci H, Sabuncu Ü, DUMLUPINAR E, Abdullayev R. Role of spinal anesthesia in the endoscopic treatment of distal, middle, and proximal ureter stones. Med J Islamic World Acad of Sci. 2018;26(2):27-30.</mixed-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <mixed-citation>Wu Y, Li C, Lu Y, Zhang J, Mei W, Wang S. Ureteroscopic lithotripsy combined with paravertebral block anesthesia or general anesthesia: A propensity matched case–control study. Asian J Surg. 2021;44(11):1370-5.</mixed-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <mixed-citation>Kwon O, Lee JM, Park J, Cho MC, Son H, Jeong H, et al. Influence of anesthesia methods on surgical outcomes and renal function in retrograde intrarenal stone surgery: a prospective, randomized controlled study. BMC Anesthesiol. 2019;19(12):1-8.</mixed-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <mixed-citation>Pelit Es, Binici O, Kati B, Yağmur İ, Demir M, Arslan E, et al. A Prospective Randomized Study Comparing Retrograde Intrarenal Surgery Under Spinal Anaesthesia Versus General Anaesthesia. J Reconst Urol. 2020;10(1):28-34.</mixed-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <mixed-citation>Dar MA, Malik SA, Dar YA, Wani PM, Wani MS, Hamid A, et al. Comparison of percutaneous nephrolithotomy under epidural anesthesia versus general anesthesia: A randomized prospective study. Urology Annals. 2021;13(3):210.</mixed-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <mixed-citation>Whitehurst L, Pietropaolo A, Geraghty R, Kyriakides R, Somani BK. Factors affecting operative time during ureteroscopy and stone treatment and its effect on outcomes: retrospective results over 6.5 years. Therap Adva Urol. 2020 Jun; 12:1756287220934403.</mixed-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <mixed-citation>Wang W, Gao X, Ma Y, Di X, Xiao K, Zhou L, et al. Regional vs general anesthesia for retrograde intrarenal surgery: A systematic review and meta-analysis. J Endourol. 2020;34(11):1121-8.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>
