JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i1.2518 jpsim.v6i1.2518 Case Report Adult Type BCR-ABL Positive CML: A Case Report of Southern Punjab Irfan Qazi Muhammad drirfanqazi@gmail.com * Khan Sana Sarwar Faiza Ahmed Ishfaq Sheikh Zayed Medical College/Hospital, Rahim Yar Khan *Correspondence: Qazi Muhammad Irfan (drirfanqazi@gmail.com) 10 03 2025 2025 6 1 86 87 15 02 2024 19 02 2025 23 02 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Chronic Myeloid Leukemia is the commonest type of myeloproliferative neoplasm. Peak age group of this illness is 27 to 66 years. The purpose of this case report is to emphasize the occurrence of rare cases and to help clinicians in diagnosing diseases with uncommon presentation. Current case report study was performed in Sheikh Zayed Medical College / Hospital Rahim Yar Khan, Pakistan from february 2022 to March 2022. A 17 years old male patient was included in this study. Complete Blood Count with peripheral smear, bone marrow aspiration and trephine biopsy were performed in Hematology department Sheikh Zayed Hospital Rahim Yar Khan, while fluorescence in situ hybridization analysis for Bcr-Abl fusion gene was performed at Agha Khan University Hospital Laboratory Karachi. Translocation was detected (98%) amongst 200 nuclei scored. Based on this study, possibility of chronic myeloid leukemia in young patients must not be ignored.

 Keywords Chronic myeloid leukemia Flourescence in situ hybridization Bcr-Abl. References Coltro G, Loscocco GG, Vannucchi AM. Classical Philadelphia-negative myeloproliferative neoplasms (MPNs): A continuum of different disease entities. International Rev Cell Mol Biol. 2021;365(1):1-69. Shallis RM, Wang R, Davidoff A, Ma X, Podoltsev NA, Zeidan AM. Epidemiology of the classical myeloproliferative neoplasms: the four corners of an expansive and complex map. Blood Rev. 2020;42(1):100706. Kim JC. Origin of disease heterogeneity in BCR-ABL1 lymphoblastic leukemia [Doctoral dissertation, University of Toronto (Canada)]. Tavares RS, Nonino A, Pagnano KB, Nascimento AC, Conchon M, Fogliatto LM, Funke VA, Bendit I, Clementino NC, Chauffaille MD, Bernardo WM. Guideline on myeloproliferative neoplasms: Associação Brasileira de Hematologia, Hemoterapia e Terapia Cellular Project guidelines: Associação Médica Brasileira–2019. Hematol Trans Cell Therap. 2019;41(Suppl 1):1-73. Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management. Am J Hematol. 2014;89(5):547-56. Risques RA, Kennedy SR. Aging and the rise of somatic cancer-associated mutations in normal tissues. PLoS Genet. 2018;14(1):e1007108.