JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i2.2527 jpsim.v6i2.2527 Original Research Effects of Fasting on Progression of Chronic Kidney Disease Siddiqui Ahreema Arshad Abdul Rehman Azeem Abdul Rehman darazeem7@gmail.com * Zahid Usama Aleem Maira Pak-Emirates Military Hospital, Rawalpindi *Correspondence: Abdul Rehman Azeem (darazeem7@gmail.com) 05 06 2025 2025 6 2 141 145 06 01 2025 22 02 2025 27 04 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective

This study aimed at examining the effects of fasting on rate of decline in renal function amongst patients with chronic kidney disease.

 Methodology

This observational study included patients with chronic kidney disease, having eGFR

 Results

There were 83 patients, predominantly males (71; 85.54%). Median serum creatinine levels were 200 (135- 302) and 220 (153- 429) umol/L at the start and end of study period, corresponding to eGFR of 24.23 (15.55, 38.13) and 19.98 (10.76, 33.72) ml/min/1.73m2 respectively, with a median decline of 2.18 (-1.03, 7.75) ml/min/1.73m2. Mean duration of fasting amongst the 25 (30.12%) patients who fasted was 25.88± 6.05 days. The median decline in eGFR amongst patients who fasted and those who did not was and 5.08 ( -0.59, 9.34) and 2.10 (-1.24, 7.50). This difference was insignificant (p=0.648).

 Conclusions

Fasting did not affect the rate of decline in renal function amongst our patients

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