To study prognostic value of pre-operative platelets to lymphocyte ratio in diabetic foot patients who underwent amputation.

This study was conducted in the surgical units of Mayo Hospital Lahore. One hundred and eighty four patients were included in the study. Data was obtained from records of patients admitted between July 2020 to July 2021. Platelet to lymphocyte ratio was noted from investigations done preoperatively. Outcome of patients was noted. Diabetic foot ulcers were classified using Wagner classification. A receiver operator curve was constructed and area under the curve was calculated. A suitable cut-off value of platelet to lymphocyte ratio was decided using the curve. Sensitivity and specificity of the cut off value as a prognostic indicator was compared between discharged and expired groups of patients using independent sample t-test.

All-cause mortality was higher in patients with high platelet to lymphocyte ratio. Area under the receiver operator curve was 0.56. Cut off value of platelet to lymphocyte ratio 244.95 calculated from receiver operator curve was found to have sensitivity of 61.8% and specificity of 53.3%. Out of 184 patients 141 (76.6%) were males and 43 (23.4%) were females with a mean age of 54.9 ± 10.47 years. One hundred and fifty patients ( 81.5%) were discharged and the remaining expired

Preoperative platelet to lymphocyte ratio can be used as a predictive biomarker of mortality in patients with diabetic foot ulcer undergoing amputation.