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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPSIM</journal-id>
      <journal-title-group>
        <journal-title>Journal of Pakistan Society of Internal Medicine</journal-title>
        <abbrev-title>J Pak Soc Intern Med</abbrev-title>
      </journal-title-group>
      <issn publication-format="print">2709-8729</issn>
      <issn publication-format="electronic">2710-0804</issn>
      <publisher>
        <publisher-name>Pakistan Society of Internal Medicine</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.70302/jpsim.v6i2.2536</article-id>
      <article-id pub-id-type="publisher-id">jpsim.v6i2.2536</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Case Report</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Hemorrhagic Encephalitis In A Young Female with Sudden Onset of Fever and Seizures</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Nazia</surname>
            <given-names>Shafaq</given-names>
          </name>
          <email>shafaq.shaikh@gmail.com</email>
          <xref ref-type="aff" rid="aff1"/>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Subhan</surname>
            <given-names>Asma</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bhatti</surname>
            <given-names>Fareeha</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Madhwani</surname>
            <given-names>Nimurta</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mumtaz</surname>
            <given-names>Fatima</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <institution>Liaquat University of Medical and Health Sciences, Jamshoro.</institution>
      </aff>
      <author-notes>
        <corresp id="cor1">*Correspondence: Shafaq Nazia (shafaq.shaikh@gmail.com)</corresp>
      </author-notes>
      <pub-date date-type="pub" publication-format="electronic" iso-8601-date="2025-06-05">
        <day>05</day>
        <month>06</month>
        <year>2025</year>
      </pub-date>
      <pub-date date-type="collection" publication-format="electronic">
        <year>2025</year>
      </pub-date>
      <volume>6</volume>
      <issue>2</issue>
      <fpage>191</fpage>
      <lpage>193</lpage>
      <history>
        <date date-type="received" iso-8601-date="2024-10-09">
          <day>09</day>
          <month>10</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd" iso-8601-date="2024-12-10">
          <day>10</day>
          <month>12</month>
          <year>2024</year>
        </date>
        <date date-type="accepted" iso-8601-date="2025-04-24">
          <day>24</day>
          <month>04</month>
          <year>2025</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright © 2025 The Author(s)</copyright-statement>
        <copyright-year>2025</copyright-year>
        <copyright-holder>The Author(s)</copyright-holder>
        <ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
          <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
        </license>
      </permissions>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v6i2.2536" content-type="text/html"/>
      <self-uri xlink:href="https://psimj.com/article/jpsim.v6i2.2536.pdf" content-type="application/pdf"/>
      <abstract>
        <p>A 16-year-old female presented to the emergency department with a sudden onset of high-grade fever and generalized tonic-clonic seizures. She was previously healthy with unremarkable medical history. Her symptoms began 4 days back. On arrival, she was semiconscious, irritable and actively seizing. Her oxygen saturation was declining rapidly. She was immediately transferred to the Intensive Care Unit (ICU) for close monitoring. Subsequent laboratory workup and MRI brain lead to the diagnosis of hemorrhagic encephalitis secondary to Herpes Simplex Virus-1 (HSV-1) infection.</p>
      </abstract>
      <kwd-group xml:lang="en" kwd-group-type="author-keywords">
        <title>Keywords</title>
        <kwd>Encephalitis</kwd>
        <kwd>Hemorrhagic encephalitis</kwd>
        <kwd>Herpes simplex virus.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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  <back>
    <ref-list>
      <title>References</title>
      <ref id="ref1">
        <label>1</label>
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        <label>2</label>
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    </ref-list>
  </back>
</article>
