JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i2.2537 jpsim.v6i2.2537 Case Report Unmasking Sturge-Weber Syndrome: A Challenging Case of Refractory Seizures, Facial Angiomas, and Glaucoma in a Young Patient Rehman Saeed Ur Shah Ahsen Rashid Majid kmciteadventurers@gmail.com * Saeed Kamran Ali Saad Department of Internal Medicine, Khyber Teaching Hospital, Peshawar, Pakistan *Correspondence: Majid Rashid (kmciteadventurers@gmail.com) 05 06 2025 2025 6 2 194 196 08 10 2024 10 12 2024 08 05 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Sturge-Weber Syndrome (SWS) is a rare congenital neurocutaneous disorder associated with a port-wine stain, leptomeningeal angioma, and glaucoma. Here, we present a case of a 16-year-old boy with classical SWS who had a history of seizures since 6 months of age, intellectual disability, and glaucoma. Imaging revealed prominent leptomeningeal enhancement affecting the right temporal and occipital. The patient received intravenous anti-epileptic medication, antibiotics, and regular follow-up was scheduled. Early detection and treatment are critical to prevent ophthalmic and cerebral complications. The management of SWS requires a multidisciplinary approach.

 Keywords Sturge-Weber Syndrome Refractory Seizures Facial Angiomas Glaucoma References Gill NC, Bhaskar N. Sturge-Weber Syndrome: A case report. Contemp Clin Dent. 2010;1(3):183-5. Tripathi AK, Kumar V, Dwivedi R, Saimbi CS. Sturge-Weber Syndrome: oral and extra-oral manifestations. BMJ Case Rep. 2015; 10.1136/bcr-2014-207663. Garro SJ, Bradshaw WT. Sturge-Weber Syndrome: a case study. Adv Neonatal Care. 2014;14(2):96-102. Welty LD. Sturge-Weber Syndrome: A case study. Neonatal Netw. 2006;25(2):89-98. Roach ES. Neurocutaneous syndromes. Pediatr Clin North Am. 1992;39:591-620. Suprabha B, Baliga S. Total oral rehabilitation in a patient with port wine stains. J Indian Soc Pedod Prev Dent. 2005;23(2):99-102. Mukhopadhyay S. Sturge-Weber Syndrome: A Case report. J Indian Soc Pedod Prev Dent. 2008;26(5):29-31. Waelchli R, Aylett SE, Robinson K, Chong WK, Martinez AE, Kinsler VA. New vascular classification of port‐wine stains: improving prediction of Sturge-Weberrisk. Br J Dermatol. 2014;171(4):861-7. Higueros E, Roe E, Granell E, Baselga E. Sturge-Weber Syndrome: A Review. Actas Dermosifiliogr. 2017;108(5):407-17. Bay MJ, Kossoff EH, Lehmann CU, Zabel TA, Comi AM. Survey of aspirin use in Sturge-Weber Syndrome. J Child Neurol. 2011;26(6):692-702. Comi A. Current Therapeutic Options in Sturge-Weber Syndrome. Semin Pediatr Neurol. 2015;22(4):295-301.