JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v6i3.2544 jpsim.v6i3.2544 Original Research Prevalence of Adverse Donor Reactions among Healthy Blood Donors Presenting in a Tertiary Care Hospital Blood Bank Ranjha Irfan irfanranjha43291@import.invalid * Chaudhary Hammad Tufail Amin Irfan Fateen Tooba Saeed Muhammad Allama Iqbal Medical College, Lahore, Pakistan Taif University, Taif, Saudi Arabia Kohsar University, Murree, Pakistan *Correspondence: Irfan Ranjha (irfanranjha43291@import.invalid) 23 08 2025 2025 6 3 239 244 14 02 2025 25 02 2025 28 07 2025 Copyright © 2025 The Author(s) 2025 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives

To determine the incidence and types of adverse donor reactions among healthy blood donors during the blood donation process.

 Methodology

In this descriptive cross-sectional study, which was carried out at Blood Bank Jinnah Hospital, Lahore, over a period of six months from Aug 2023 to Jan 2024, a total of 550 healthy blood donors aged 18-60 years fulfilling the donation criteria were enrolled. After the informed consent, the study participants were observed during the whole donation process. Collected data were analyzed using SPSS software.

 Results

Data from 550 donors consisting of 543 males and 7 females revealed mean age, height and weight of 28 years, 167 cm and 71 kg respectively. 484 (88%) were Rh positive blood groups and 66 (12%) were Rh negative groups. 28 (5.1%) donors experienced some adverse reactions and all were males. 8 (28%) of 28 were donating for the first time. All the reactions were mild to moderate in nature and no medical emergency or life- threatening situation appeared. 8 (28%) had slow pulse and fall in BP, 5 (18%) had nausea, 3 (10%) fainted, 3 (10%) were double pricked, 2 (7%) experienced warmth and head sweating, 2 (7%) had cold extremities, 2 (7%) had pain at the local site, 1 (4%) vomited, 1 (4%) felt fatigue, and 1 (4%) developed a hematoma.

 Conclusion

Blood donation is a safe and risk-free procedure as only a few donors have experienced mild to moderate reactions. Proper training of blood bank staff and counselling of blood donors can reduce these adverse events more effectively.

 Keywords Blood Donation Blood Donor Adverse reactions Blood bank Tertiary care hospital Lahore. Ethics Statement

Ethics committee: Institutional Review Board / Ethics Committee (IRB/EC). Approval number: ERB150/3/14-09-2023/S1, dated September 14, 2023.

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