JPSIM Journal of Pakistan Society of Internal Medicine J Pak Soc Intern Med 2709-8729 2710-0804 Pakistan Society of Internal Medicine 10.70302/jpsim.v7i2.2623 jpsim.v7i2.2623 Original Research Association of Serum Resistin with Insulin Sensitivity in Self Reported Healthy Individuals of Pakistan: A Cross-Sectional Study Areej Khuldiya Shafaq Maryam Imran Muhammad Mehmood Anum Muddassir Maria marya.b@live.com * Hadi Faheem The University of Lahore, Pakistan Nishtar Medical University, Multan, Pakistan Hub of Dental Experts, Lahore, Pakistan M Islam Medical & Dental College, Gujranwala, Pakistan The Islamia University of Bahawalpur, Bahawalpur, Pakistan *Correspondence: Maria Muddassir (marya.b@live.com) 03 06 2026 2026 7 2 116 121 01 04 2025 09 04 2026 04 05 2026 Copyright © 2026 The Author(s) 2026 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives

In current study, it was aimed to evaluate relationship between level of serum resistin and some metabolic and anthropometric parameters of healthy individuals.

 Methodology

Eighty healthy subjects with mean body mass index of 25 kg/m2 or greater were added. Waist to hip ratio, body mass index, weight and height were calculated as anthropometric parameters. Lipid profiles, blood insulin level, plasma glucose level, fasting serum resistin and insulin resistance (by homeostasis model assessment, HOMA) were measured as metabolic parameters.

 Results

The results showed no correlation between markers and serum resistin level for uric acid level, glucose, blood pressure and adiposity. Level of serum resistin did not correlate with HOMA and fasting insulin level in women only and with high-density lipoprotein cholesterol level in men only. HDL-C level was an independent significant predictor for resistin in men only and HDL-C level and HOMA were independent significant predictors for resistin in women only, revealed by multiple linear regression analysis using the logarithm of resistin as a dependent variable.

 Conclusion

In summary, resistin was not linked to the majority of lipid profiles, insulin resistance, blood pressure, obesity, or fasting plasma glucose levels. For both men and women, resistin had a negative correlation with HDL-C levels. More research is necessary to fully understand the role of resistin in metabolic syndrome.

 Keywords Adipocytokines diabetes mellitus resistin obesity insulin resistance Ethics Statement

Ethics committee: Institutional Review Board / Ethics Committee (IRB/EC). Approval number: IMBB/BBBC/22/271, dated February 04, 2022.

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