Co-Relation Between Glycated Hemoglobin (HbA1c) and Dyslipidemia in Type II Diabetics Presenting in a Tertiary Care Hospital in Pakistan
AbstractDiabetes is a global disease that is affecting both developing and developed countries. According to a WHO survey (1994-1998), the overall prevalence of diabetes Mellitus is 11.47% in Pakistan. Based on a study done in Pakistan in 2015, the prevalence of dyslipidemia among people with diabetes was 95%. Both HbA1c and dyslipidemia lead to an increased risk for cardiovascular diseases. This study aims to identify the atherosclerotic disease risk factors among the Pakistani population to decrease morbidity and mortality. To determine the frequency of dyslipidemia among Type 2 Diabetic patients and compare dyslipidemia among Type 2 Diabetic patients with/without elevated Glycated hemoglobin (HbA1c).
MethodsA descriptive, cross-sectional study was performed at Internal Medicine Department, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, for Six months (Feb 02, 2020, till Jul 01, 2020). HbA1c levels, serum lipid profile, random and fasting blood sugar levels were tested. Non-probability consecutive sampling was done, and 100 patients were registered.
Results Out of 100 patients, 47 were males and 53 females with a mean age of 47.85 ± 8.61. Sixty-nine diabetic patients with elevated HbA1c showed a positive relationship with total cholesterol and LDL-C level (p<0.05). In addition, patients with HbA1c higher than 7% showed a high risk and borderline dyslipidemia.
Conclusion Elevated HbA1c, apart from being a glycemic index, is a good predictor of dyslipidemia. Therefore, patients with borderline or desirable lipid profile values with high HbA1c levels should start statin therapy or lifestyle modification to prevent cardiovascular diseases.
Keywords:Diabetes mellitus, Dyslipidemia, High Glycated Hemoglobin, uncontrolled diabetes.
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