A Rare Case of Area Postrema Variant (Intractable Vomiting andHiccups) of Neuromyelitis Optica Spectrum Disorder (NMOSD) in a25 Year Female Patient


  • Author- Jawad Hussain, Faizan Banaras, Tehrim Tahir, Ramish Fayyaz, Mahnoor Ashfaq, Muhammad Usman, Ali Raza


Nausea and vomiting are commonest complaints in an emergency department in hospitals. Neuromyelitis optica spectrum disorders (NMOSDs) are CNS autoimmune disorders related to highly specific biomarkers for astrocytic water channel aquaporin-4. Area postrema syndrome (APS) is described as intractable nausea, vomiting, or hiccups that can be intermittent or may persist longer than 48 hours, and other pathologies should be excluded, as may be misdiagnosed with digestive system disorders.


Neuromyelitis optica spectrum disorders, Chemo trigger zone, Intractable nausea.