Sodium Imbalance and In-Hospital Mortality in Patients Presenting with Sepsis at Tertiary Care Hospital


  • Author- Marium Khurshid, Madiha Iqbal, Sohail Lakhani, Zara Nadeem, Syeda Zeenat Sahar Junaid, Areesh Mevawalla, Ainan Arshad


Objective: To determine if presenting hyponatremia in septic patients is associated with higher in-hospital mortality.


: This study was conducted at Aga Khan University Hospital Karachi, in the department of medicine for the duration of 6 months after ERC approval. Sample size of the study was 153 by taking prevalence of severe hyponatremia 15.8%, with margin of error = 6% and CI=95%. Those patients who were admitted with diagnosis of sepsis aged above 20 years were included in the study. Data was collected and recorded in computers, results were generated by using SPSS recent version and analysis was done by analyst.


 : During the selected time frame for the study 153 patients were included in the study. Table-1 described the patient demographics, clinical characteristic and outcome of the patients included in the study, and comparison has been done amongst the two groups, with and without hyponatremia. Overall mortality in our study was found to be 39%, out of which 43.8% had hyponatremia, and 29.3% were with normal sodium levels. Females comprised of 51.2% of hyponatremic patients and 45.5% of normal serum sodium group. The SOFA score between these two groups did not show any significant difference. Patients with hyponatremia group had prolonged complicated hospital stay and required invasive ventilation (%) and had an increased mortality rate (43.8%) in comparison to patients who had normal sodium levels (29.3%).


 : Hyponatremia at presentation is not associated with higher in-hospital mortality in patients with sepsis.


: Hyponatremia, Sepsis, Sepsis-3, ICU