The SARS-CoV-2 and Human Immune System


  • Author- Mulazim Hussain Bukhari, Somia Iqtadar, Ahmed Uzair Qureshi


The genetic make up of the COVID-19, critical patients in ICUs was compared with the genomes of healthy person to identify any genetic differences. It was found that few genes like, TYK2 are seen in such patients which makes the immune cells more annoyed resulting in more inflammatory response. But if the gene is faulty, the patients hyper immune response can go into overdrive, putting him at risk of pulmonary injury and cytokine storm (CS). This analysis highlights the unique characteristics of patients with COVID-19 disease that genomic and laboratory parameters present an imbalance in cytokine storm players (pro inflammatory stage, cell death, multi-organ tissue destruction, and electrolyte imbalance).


COVID-19, Genes, Immune system, Overrides, SARS-Cov-2, TYK2, Critical stages, ICUs.