Risk Factors, Frequency and Outcome of New-Onset Diabetes Mellitus
in Inflammatory Bowel Disease: Three-Year Follow-up Study
AbstractResearch was conducted to analyze the Risk factors, frequency and outcome of new-onset of diabetes mellitus in inflammatory bowel disease patients.
MethodsThis review was conducted at a Tertiary care setup of Pakistan, it is a retrospective study of evaluation of IBD patients presented during the period of 2012-2017. Medical records were then analyzed to determine if they developed new-onset of diabetes mellitus within three years. If so, outcome measures were compared in the diabetic and non-diabetic group.
Results  364 patients were enrolled in the study. 206 (57%) were males and 158 (43.4%) were females; average mean age for diagnosis of IBD patients was 28.5 ± 8.0 years. 19 (5.2%) patients went on to develop new-onset DM. Majority of patients were of the ulcerative colitis. Risk factors for developing new onset of DM in IBD patients were female gender (p= 0.026), previous history of hypertension (p= <0.001) and previous history of ischemic heart disease (p= 0.004). Patients who developed DM had a significantly higher number of flares within the next three years (p= 0.001).
Conclusion  We concluded that patients of Inflammatory Bowel Disease (IBD) are at a significant risk of developing new-onset DM irrespective of steroid treatment. Furthermore, these patients are prone to an increased number of flares in the long run. Hence, we believe that these results warrant early screening and watch for glycemic control in IBD to improve long-term outcomes.
Keywords:Diabetes Mellitus, Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
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