Mean Platelet Volume and Acute Stroke Patient Characteristics
AbstractPlatelet indices are considered as an important marker of inflammation and thromboembolism. Out of these platelet indices, mean Platelet volume (MPV) changes have been associated with cardiovascular diseases. The objective of this study was to compare MPV in patients with ischemic and hemorrhagic acute stroke. Additionally, correlation of MPV with gender, risk factors, severity of stroke, and outcome was also done.
MethodsThis cross-sectional study was conducted from October 2018 to March 2019 at Rawalpindi Medical University Allied Hospitals. 94 acute stroke patients (ischemic or hemorrhagic- intracerebral or non-traumatic subarachnoid hemorrhage) were included. Patients with stroke mimicking conditions, hematological abnormalities associated with platelet number/quality, and on antiplatelet and anticoagulant drug etc. were excluded. At presentation blood sample was drawn for MPV determination by single automated hematology analyzer machine within 2 hours of venipuncture. Chi2 test, Fishers exact test, Student-t test, and ANOVAwere used for finding significant association. P-value < 0.05 taken as statistically significant.
Results  53.2% were female and the rest male. Mean patient age was 58.67±16.37 years. 59.75% patients had hemorrhagic stroke and 40.4% had ischemic stroke. Most frequently noted risk factors for stroke were hypertension (53.2%) and diabetes mellitus (16%). 94.7% patients at admission Modified Rankin Score was >3. Mean GCS of all patients was 9.9 ± 3.79. MPV of all the patients were 8.9±0.85 Similarly, mean platelet count was 268.26±76.06x103/l. On 7th day of admission, outcome wise, 88.3% patients were alive and rest expired. MPV among ischemic and hemorrhagic patients did not differ significantly. Correlation of patient's characteristics with MPVwas also statistically insignificant.
Conclusion  MPV in ischemic and hemorrhagic acute stroke patients doesn't differ. MPV values are also not associated significantly with gender, risk factors, stroke severity and outcome.
Keywords:Mean Platelet Volume, Acute Stroke, Intracranial Hemorrhage.
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