Immunoreactivity of Thyroid Trabscription Factor-1 for Diagnosis of Primary Breast Carcinoma
MethodsThe cross-sectional study was conducted at University of Lahore, Lahore. A total of 110 cases of primary breast carcinomas were included.TTF-1 immunohistochemistry was performed. However, the frequency with which TTF-1 expression is observed in breast carcinomas is unknown. To address this, we carried out Immunohistochemical staining for TTF-1 on primary breast carcinomas submitted for routine estrogen receptor, progesterone receptor, and HER2 testing.
Results  A total of 110 cases were selected for this study according to our inclusion criteria. There were 105 female patients (95.45%) and 5 male patients (4.55%). A total of 6 (5.45%) cases were positive for TTF-1 as compared to 104 (94.5%) negative cases. The data was stratified according to age and gender. Chi-square test was applied with significant results kept at p=0.05. There was no significant association between TTF-1 expression in males and females and different age groups (P=0.143 for gender and p=0.223 for age groups).
Conclusion  Expression varied from focal and weak to diffuse and strong and was seen in both invasive and in situ components. We conclude that a small proportion of breast carcinomas show TTF-1 expression. Therefore, the presence of TTF-1 immunoreactivity in a carcinoma cannot by itself be used to exclude the possibility of a breast origin.
Keywords:Thyroid transcription factor, Immunohistochemical stain, Breast carcinomas.
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments firstname.lastname@example.org