Original Research

Alcohol Intake: A Risk to Develop Type-2 Diabetes Mellitus-Think Before You Drink

DOI https://doi.org/10.70302/jpsim.v1i1.2007
Received: 19 Sep 2020 Accepted: 14 Oct 2020 Published Online: 16 Dec 2020

Abstract

Objectives

A toxic substance, alcohol is psychotropic in nature and bears dependence producing propensities. The excessive use of alcohol is a global health concern and the world's leading risk factor for disease and disability. This study aim was to investigate the link between alcohol intake and occurrence of type 2 diabetes mellitus (T2DM) amongst male and female alcohol users.

Subjects and Methods

In this study 52original studies were recognized using search engines including “Medline”, “Web of Science”, “Pub-Med”, “Scopus”, and“ EMBASE” using various keywords like “alcohol intake” “alcohol consumption” “incidence”, “Diabetes Mellitus” “type-2 Diabetes Mellitus”. Finally, 12 original research articles were included with a total sample size of 182,422, from them 120243 (65.92%) were males and 62179 (34.08%) were females. T2DM pooling incidence was analyzed using random and fixed model effects.

Results

The prevalence of Type 2 diabetes mellitus among male alcohol users was 7% with 95% confidence interval 5%-11%. However, the prevalence of T2DM among female alcohol users was 6%with 95% confidence interval was 5%-9%. The pooled incidence of T2DM was higher in males compared to females.

Conclusion

Alcohol intake is a risk to develop T2DM. The findings have a general message for the global health community on the potential harms of alcohol intake on T2DM. A healthy lifestyle pattern could be adopted and alcohol governing policies should be implanted. Health educational awareness programs should be introduced to highlight the hazardous effects of alcohol and its association with T2DM. Alcohol users must think before to drink.

Keywords
Alcohol Type 2 Diabetes Mellitus Prevalence.

How to Cite This Article

Meo SA, Ullah A. Alcohol Intake: A Risk to Develop Type-2 Diabetes Mellitus-Think Before You Drink. J Pak Soc Intern Med. 2020;1(1):20–27. doi:10.70302/jpsim.v1i1.2007

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. World Health Organization. Alcohol: [Updated 2020] Available at: [https://www.who.int/health-topics/alcohol].
  2. Lasebikan VO, Ayinde O, Odunleye M, Adeyefa B, Adepoju S, Fakunle S. Prevalence of alcohol consumption and alcohol use disorders among outdoor drinkers in public openplaces in Nigeria. BMC Public Health 2018; 18(1): 400.
  3. Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G. Alcoholic disease: liver and beyond. World J Gastroenterol 2014; 20(40):14652-9.
  4. Manicone PF1, Tarli C, Mirijello A, Raffaelli L, Vassallo GA, Antonelli M, Rando MM, Mosoni C, Cossari A, Lavorgna L, Caputo F, D'Addona A, Gasbarrini A, Addolorato G. Dental health in patients affected by alcohol use disorders: a cross-sectional study. Eur Rev Med Pharmacol Sci 2017; 21(22): 5021-7.
  5. Vassallo GA, Mirijello A, Tarli C, Rando MM, Antonelli M, Garcovich M, Zocco MA, Sestito L, Mosoni C, Dionisi T, D'Addio S, Tosoni A, Gasbarrini A, Addolorato G. Madelung's disease and acute alcoholic hepatitis: case report and review of literature. Eur Rev Med Pharmacol Sci. 2019; 23(14):6272-6.
  6. Meo SA, Usmani AM, Qalbani E. Prevalence of type 2 diabetes in the Arab world: impact of GDP and energy consumption. Eur Rev Med Pharmacol Sci 2017; 21(6): 1303-12.
  7. Meo SA, Memon AN, Sheikh S, Rouq FA, Usmani AM, Hassan A, Arian SA. Effect of environmental air pollution on type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci 2015; 19(1) 123-128.
  8. Meo SA, AlMutairi FJ, Alasbali MM, Alqahtani TB, AlMutairi SS, Albuhayjan RA, Al-Rouq F, Ahmed N. Men's Health in Industries: Plastic Plant Pollution and Prevalence of Pre-diabetes and Type 2 Diabetes Mellitus.Am J of Men’s Health 2018; 12(6): 2167-72.
  9. Han T, Zhang S, Duan W, Ren X, Wei C, Sun C, Li Y. Eighteen-year alcohol consumption trajectories and their association with risk of type 2 diabetes and its related factors: the China Health and Nutrition Survey. Diabetologia. 2019; 62(6): 970-80.
  10. Knott CS, Britton A, Bell S. Trajectories of alcohol consumption prior to the diagnosis of type 2 diabetes: a longitudinal case-cohort study. Int J Epidemiol. 2018; doi: 10.1093/ije/dyx274. doi:10.1093/ije/dyx274
  11. Kerr WC, Williams E, Li L, Lui CK, Ye Y, Greenfield TK, Lown EA. Alcohol use patterns and risk of diabetes onset in the 1979 National Longitudinal Survey of Youth Cohort. Prev Med. 2018; 109(4): 22-27.
  12. Lim J, Lee JA, Cho HJ. Association of Alcohol Drinking Patterns With Presence of Impaired FastingGlucose and Diabetes Mellitus Among South Korean Adults. J Epidemiol. 2018; 28(3): 117-24.
  13. Peng M, Zhang J, Zeng T, Hu X, Min J, Tian S. Alcohol consumption and diabetes risk in a Chinese population: a Mendelian randomization analysis. Addiction. 2019 114(3):436-49.
  14. Holst C, Becker U, Jørgensen ME, Grønbæk M, Tolstrup JS. Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population. Diabetologia. 2017; 60(10):1941-50.
  15. Koloverou E, Panagiotakos DB, Pitsavos C, Chrysohoou C, Georgousopoulou EN, Metaxa V, Stefanadis C. Effects of alcohol consumption and the metabolic syndrome on 10-year incidence of diabetes: the ATTICA study. Diabetes Metab. 2015; 41(2):152-9.
  16. Hong SW, Linton JA, Shim JY, Kang HT. High-risk drinking is associated with a higher risk of diabetes mellitus in Korean men, 2010-2012 KNHANES. Alcohol. 2015; 49(3):275-81.
  17. Liang W, Chikritzhs T. Alcohol consumption during adolescence and risk of diabetes in young adulthood. Biomed Res Int. 2014; https://doi.org/10.1155/2014/795741. doi:10.1155/2014/795741
  18. Djoussé L, Biggs ML, Mukamal KJ, Siscovick DS. Alcohol consumption and type 2 diabetes among older adults: the Cardiovascular Health Study. Obesity. 2007; 15(7):1758-65.
  19. Waki K, Noda M, Sasaki S, Matsumura Y, Takahashi Y, Isogawa A, Ohashi Y, Kadowaki T, Tsugane S; JPHC Study Group. Alcohol consumption and other risk factors for self-reported diabetes among middle-aged Japanese: a population-based prospective study in the JPHC study cohort I. Diabet Med 2005; 22(3): 323-31.
  20. Kao WH, Puddey IB, Boland LL, Watson RL, Brancati FL. Alcohol consumption and the risk of type 2 diabetes mellitus: atherosclerosis risk in communities study. Am J Epidemiol. 2001; 154(8):748-57.
  21. International Diabetes Federation (IDF) Atlas. 9thEdition. [Updated 2019]. Available at [https://www.diabetesatlas.org/en/sections/worldwide-toll-of-diabetes.html].
  22. 22 Lai YJ, Hu HY, Lee YL, Ko MC, Ku PW, Yen YF. Frequency of alcohol consumption and risk of type 2 diabetes mellitus: A nationwide cohort study. Clin Nutr. 2019; 38(3): 1368-72.
  23. Hodge AM, English DR, O’Dea K, Giles GG. Alcohol intake, consumption pattern and beverage type, and the risk of Type 2 diabetes. Diabet Med. 2006; 23(6): 690-7.
  24. Wannamethee SG, Camargo CA Jr, Manson JE, Willett WC, Rimm EB. Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Arch Intern Med. 2003; 163(11):1329-36.
  25. Baliunas DO, Taylor BJ, Irving H, Roerecke M, Patra J, Mohapatra S , Rehm J. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2009; 32(11): 2123-32.
  26. Vancampfort D, Mugisha J, Hallgren M, De Hert M, Probst M, Monsieur D, Stubbs B. The prevalence of diabetesmellitustype2 in people with alcohol use disorders: a systematicreview and largescalemeta-analysis. Psychiatry Res. 2016; 246(12):394-400.
  27. Marques-Vidal P, Vollenweider P, Waeber G. Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study. Nutr Metab Cardiovasc Dis. 2015; 25(1):75-84.
  28. Cullmann M, Hilding A, Östenson CG. Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population. Diabet Med. 2012; 29(4): 441-52.
  29. Howard AA, Arnsten JH, Gourevitch MN. Effect of alcohol consumption on diabetes mellitus: a systematic review. Ann Intern Med 2004; 140(3):211-9.
  30. Xu D, Dhillon AS, Abelmann A, Croft K, Peters TJ, Palmer TN. Alcohol-related diols cause acute insulin resistance in vivo. Metabolism 1998; 47(10): 1180-6.

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