Original Research

Immunoreactivity of Thyroid Trabscription Factor-1 for Diagnosis of Primary Breast Carcinoma

Amber Hassan1
Faculty of Allied Health Sciences, The University of Lahore, Lahore
Imrana Tanvir2
Pathology Department, King Abdul Aziz University, Rabigh, Saudi Arabia
Riffat Mehboob1
Faculty of Allied Health Sciences, The University of Lahore, Lahore
Syed Amir Gillani1
Faculty of Allied Health Sciences, The University of Lahore, Lahore
Fridoon Jawad Ahmad3
Department of Physiology, University of Health Sciences, Lahore
Muhammad Akram Tariq3
Department of Physiology, University of Health Sciences, Lahore
Gibran Ali3
Department of Physiology, University of Health Sciences, Lahore
Shehla Javed Akram4
Akram Medical Complex, Lahore
Javed Akram5
Vice Chancellor: University of Health Sciences, Lahore

✉ Correspondence: Javed Akram Email: jakramaimc@gmail.com

DOI https://doi.org/10.70302/jpsim.v1i1.2008
Volume: 1, Issue 1 Pages: 28–34 Published: 16 Dec 2020
Received: 24 Sep 2020 Accepted: 19 Oct 2020 Published Online: 16 Dec 2020

Abstract

Objective

To determine the Immunolocalization of TTF-1 in primary breast carcinomas

Methods

The cross-sectional study was conducted at University of Lahore, Lahore. A total of 110 cases of primary breast carcinomas were included.TTF-1 immunohistochemistry was performed. However, the frequency with which TTF-1 expression is observed in breast carcinomas is unknown. To address this, we carried out Immunohistochemical staining for TTF-1 on primary breast carcinomas submitted for routine estrogen receptor, progesterone receptor, and HER2 testing.

Results

A total of 110 cases were selected for this study according to our inclusion criteria. There were 105 female patients (95.45%) and 5 male patients (4.55%). A total of 6 (5.45%) cases were positive for TTF-1 as compared to 104 (94.5%) negative cases. The data was stratified according to age and gender. Chi-square test was applied with significant results kept at p=0.05. There was no significant association between TTF-1 expression in males and females and different age groups (P=0.143 for gender and p=0.223 for age groups).

Conclusions

Expression varied from focal and weak to diffuse and strong and was seen in both invasive and in situ components. We conclude that a small proportion of breast carcinomas show TTF-1 expression. Therefore, the presence of TTF-1 immunoreactivity in a carcinoma cannot by itself be used to exclude the possibility of a breast origin

Keywords
Thyroid transcription factor Immunohistochemical stain Breast carcinomas.

How to Cite This Article

Hassan A, Tanvir I, Mehboob R, Gillani SA, Ahmad FJ, Tariq MA, et al.. Immunoreactivity of Thyroid Trabscription Factor-1 for Diagnosis of Primary Breast Carcinoma. J Pak Soc Intern Med. 2020;1(1):28–34. doi:10.70302/jpsim.v1i1.2008

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2020 Journal of Pakistan Society of Internal Medicine.
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