Review Article

The SARS-CoV-2 and Human Immune System

Mulazim Hussain Bukhari1
Azra Naheed Medical College, Lahore
Somia Iqtadar2
King Edward Medical University, Lahore
Ahmed Uzair Qureshi3
Services Institute of Medical Science, Lahore

✉ Correspondence: Mulazim Hussain Bukhari Email: mulazim.hussain@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i1.2103
Volume: 2, Issue 1 Pages: 5–9 Published: 13 Mar 2021
Received: 20 Nov 2020 Accepted: 11 Jan 2021 Published Online: 13 Mar 2021

Abstract

The genetic make up of the COVID-19, critical patients in ICUs was compared with the genomes of healthy person to identify any genetic differences. It was found that few genes like, TYK2 are seen in such patients which makes the immune cells more annoyed resulting in more inflammatory response. But if the gene is faulty, the patients hyper immune response can go into overdrive, putting him at risk of pulmonary injury and cytokine storm (CS). This analysis highlights the unique characteristics of patients with COVID-19 disease that genomic and laboratory parameters present an imbalance in cytokine storm players (pro inflammatory stage, cell death, multi-organ tissue destruction, and electrolyte imbalance).

Keywords
COVID-19 Genes Immune system Overrides SARS-Cov-2 TYK2 Critical stages ICUs.

How to Cite This Article

Bukhari MH, Iqtadar S, Qureshi AU. The SARS-CoV-2 and Human Immune System. J Pak Soc Intern Med. 2021;2(1):5–9. doi:10.70302/jpsim.v2i1.2103

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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