Original Research

Mean Platelet Volume and Acute Stroke Patient Characteristics

Najia Mahmood
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan
Nida Anjum
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan
Muhammad Khurram
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan
Abdul Salam
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan
Madeeha Nazar
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan
Sadaf Rafique
Medical Unit-II, Holy Family Hospital/Rawalpindi Medical University, Rawalpindi, Pakistan

✉ Correspondence: Madeeha Nazar Email: madeehanazar@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i1.2107
Volume: 2, Issue 1 Pages: 24–28 Published: 13 Mar 2021
Received: 04 Dec 2020 Accepted: 07 Jan 2021 Published Online: 13 Mar 2021

Abstract

Objective

Platelet indices are considered as an important marker of inflammation and thromboembolism. Out
of these platelet indices, mean Platelet volume (MPV) changes have been associated with cardiovascular
diseases. The objective of this study was to compare MPV in patients with ischemic and hemorrhagic acute
stroke. Additionally, correlation of MPV with gender, risk factors, severity of stroke, and outcome was also
done.

Methods

This cross-sectional study was conducted from October 2018 to March 2019 at Rawalpindi Medical
University Allied Hospitals. 94 acute stroke patients (ischemic or hemorrhagic- intracerebral or non-traumatic
subarachnoid hemorrhage) were included. Patients with stroke mimicking conditions, hematological
abnormalities associated with platelet number/quality, and on antiplatelet and anticoagulant drug etc. were
excluded. At presentation blood sample was drawn for MPV determination by single automated hematology
analyzer machine within 2 hours of venipuncture. Chi2 test, Fishers exact test, Student-t test, and ANOVAwere
used for finding significant association. P-value < 0.05 taken as statistically significant.

Results

53.2% were female and the rest male. Mean patient age was 58.67±16.37 years. 59.75% patients had
hemorrhagic stroke and 40.4% had ischemic stroke. Most frequently noted risk factors for stroke were
hypertension (53.2%) and diabetes mellitus (16%). 94.7% patients at admission Modified Rankin Score was
>3. Mean GCS of all patients was 9.9 ± 3.79. MPV of all the patients were 8.9±0.85 Similarly, mean platelet
count was 268.26±76.06x103/l. On 7th day of admission, outcome wise, 88.3% patients were alive and rest
expired. MPV among ischemic and hemorrhagic patients did not differ significantly. Correlation of patient's
characteristics with MPVwas also statistically insignificant.

Conclusion

MPV in ischemic and hemorrhagic acute stroke patients doesn't differ. MPV values are also not
associated significantly with gender, risk factors, stroke severity and outcome.

Keywords
Mean Platelet Volume Acute Stroke Intracranial Hemorrhage.

How to Cite This Article

Mahmood N, Anjum N, Khurram M, Salam A, Nazar M, Rafique S. Mean Platelet Volume and Acute Stroke Patient Characteristics. J Pak Soc Intern Med. 2021;2(1):24–28. doi:10.70302/jpsim.v2i1.2107

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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