Review Article

Why Ivermectin, Azithromycin, Meplazumab and Vitamin D Helps to Control the Severity of SARS-CoV-2. The Role of ACE-2 and CD147 During Coronavirus Infection

Mulazim Hussain Bukhari
Azad Jammu Kashmir Medical College, Muzaffarabad
Wajiha Rizwan
Azad Jammu Kashmir Medical College, Muzaffarabad

✉ Correspondence: Mulazim Hussain Bukhari Email: mulazim.hussain@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i3.2145
Volume: 2, Issue 3 Pages: 190–194 Published: 20 Sep 2021
Received: 02 May 2021 Accepted: 31 Jul 2021 Published Online: 20 Sep 2021

Abstract

As the world faces pandemic of COVID-19, the search for effective treatments modalities against the disease and its
complications has turned its gaze to drugs that are classically used in other infectious diseases.
Some drugs are being examined for the recent evidence on its effects on viral replication and inflammation. The aim of the study was to review the mechanism of action of Ivermectin, Azithromycin, Hydroxycholoquine, and vitamin D therapy being used in the literature. This review found that the drugs might mitigate disease progression without significant adverse effects and can be used prophylactically, during the disease and after recover when in long hauler state. Further cohort studies are needed in order to extrapolate these findings in COVID-19. The discovery of CD147 will open the channel to discover some new more potent target therapeutic drugs.

Keywords
Coronavirus COVID-19 Ivermectin. ACE2 CD147 Lucine Histidine SARS-CoV-2

How to Cite This Article

Bukhari MH, Rizwan W. Why Ivermectin, Azithromycin, Meplazumab and Vitamin D Helps to Control the Severity of SARS-CoV-2. The Role of ACE-2 and CD147 During Coronavirus Infection. J Pak Soc Intern Med. 2021;2(3):190–194. doi:10.70302/jpsim.v2i3.2145

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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