Original Research

Platelet Indices in Diabetes Mellitus Indicating Severity of Diabetic Microvascular Complications

Mehwish Mustafa1
Hameed Lateef Hospital, Lahore
Muhammad Naveed Aslam2
DHQ Hospital, Gujranwala
Ahmad Hameed3
Department of Pathology, KEMU Lahore
Safana Sadaf4
Chughtai Institute of Pathology, Lahore
Muhammad Arif Nadeem5
Services Hospital, Lahore

✉ Correspondence: Muhammad Arif Nadeem Email: arifnadeem1234@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i3.2148
Volume: 2, Issue 3 Pages: 209–214 Published: 20 Sep 2021
Received: 10 Jun 2021 Accepted: 08 Aug 2021 Published Online: 20 Sep 2021

Abstract

Objective

The main purpose of this article was to compare the platelet volume parameter in patients with and without diabetic micro vascular complications and to evaluate the relationship and link between platelet volume indices and severity of micro vascular complications in diabetics.

Method

This cross sectional comparative study was carried out at Diabetic Clinic of Mayo Hospital Lahore from 23-01-
2015 to 31-07-2015. Sample size of 444 well controlled (on oral hypoglycemic) diabetic patients above 30 years of age
from both gender were taken with exclusion of having any haematological disorder, end stage renal disease, ischemic heart disease, stroke, any malignancy or usage of antiplatelet drugs. Venous blood samples of all patients were analyzed for full
blood count. Midstream urine specimens of all patients were analyzed by spot urine protein to creatinine ratio for
quantification of proteinuria. Fundoscopy of all patients were done by ophthalmologist of Ophthalmology Department of same hospital. Neurological examination of all patients for peripheral neuropathy was done.

Results

Four hundred and forty four patients, 185 male (41.7 %) and 259 female (58.3%) with mean age of 52.4 ±7.9 years having good control (on oral hypoglycemic) diabetic patients were enrolled for study. In this study, 222 (50%) patients were without complications, 52 (11.7%) patients were with nonproliferative retinopathy (NPDR), 14 (3.2%) patients were with proliferative retinopathy (PDR), 54 (12.2%) patients had early nephropathy, 25 (5.6%) patients had advanced nephropathy, 30 (6.8%) patients had early neuropathy, 24 (5.4%) patients had advanced neuropathy and 23 (5.2%) patients had 2 complications. Patients with diabetic microvascular damage have high MPV values as compared to diabetics without these damage (P< 0.0001). Same results were observed for PDWvalues (P< 0.0001).

Conclusion

Platelet volume indices (PVI) are high in diabetics with early and advanced micro vascular damage as compared to diabetics without micro vascular damage.

Keywords
Diabetes mellitus platelet volume parameter retinopathy neuropathy nephropathy.

How to Cite This Article

Mustafa M, Aslam MN, Hameed A, Sadaf S, Nadeem MA. Platelet Indices in Diabetes Mellitus Indicating Severity of Diabetic Microvascular Complications. J Pak Soc Intern Med. 2021;2(3):209–214. doi:10.70302/jpsim.v2i3.2148

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. Ferreiro JL, Gómez-Hospital JA, Angiolillo DJ. Platelet abnormalities in diabetes mellitus. DiabVasc Dis Res. 2010;7(4):251-9.
  2. Genuth S, Alberti KG, Bennett P. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003; 26(11):3160-7.
  3. Vazzana N, Ranalli P, Cuccurullo C, Davì G. Diabetes mellitus and thrombosis.Thromb Res. 2012;129(3):371-7.
  4. Lüscher TF, Creager MA, Beckman JA and Cosentino F. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part II. Circulation 2003;108(1):1655-61.
  5. Creager MA, Lüscher TF, Cosentino F and Beckman JA. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation. 2003;108(1):1527-32.
  6. Osende JI, Badimon JJ, Fuster V. Blood thrombogenicity in non insulin dependent diabetes mellitus patients is associated with glycemic control. J Am Coll Cardiol 2001;38(5):1307-12.
  7. Kim JH, Bae HY, Kim SY. Clinical marker of platelet hyperreactivity in diabetes mellitus. Diabetes Metab J. 2013;37(6):423-8.
  8. Senzel L, Gnatenko DV, Bahou WF. The platelet proteome. Curr Opin Hematol. 2009; 16(5):329-33.
  9. Randriamboavonjy V, Fleming I. Platelet function and signaling in diabetes mellitus. Curr Vasc Pharmacol 2012;10(5):532-8.
  10. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357(24):2482-94.
  11. Kodiatte TA, Manikyam UM, Rao SB, Jagadish TM, Reddy M, Lingaiah HKM and Lakshmaiah V Mean Platelet Volume in Non insulin dependent Diabetes Mellitus. J Lab Physicians. 2012;4(1): 5-9.
  12. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012;44(8):805-16.
  13. Yenigün EC, Okyay GU, Pirpir A, Hondur A, Yıldırım IS. Increased mean platelet volume in non insulin dependent diabetes mellitus. Dicle Med J 2014;41(1):17- 22.
  14. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, Singh S. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology. 2011;16(2):86-9.
  15. Dindar S, Cinemre H, Sengul E, Annakkaya AN. Mean Platelet volume is associated with glycemic control and retinopathy in patients with non-insulin dependent diabetes mellitus.West Indian Med J. 2013; 62(6): 519-23.
  16. Shilpi K and Potekar RM. A Study of Platelet Indices in Non-insulin dependent Diabetes Mellitus Patients. Indian J Hematol Blood Transfus. 2018 Jan; 34(1): 115-120.
  17. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta analysis. J Thromb Haemost 2010;8(1):148 56.
  18. Buch A, Kaur S, Nair R, Jain A. Platelet volume indices as predictive biomarkers for diabetic complications in Non-insulin dependent diabetic patients. J Lab Phy. 2017;9(2):84.
  19. Ateş O, Kiki I, Bilen H, Keleş M, Koçer I, Kulaçoğlu DN. Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus. Eur J Gen Med. 2009;6(2): 99–102.
  20. Dayal A, Kothari S, Shah RJ and Patel SM. MPV in Diabetes Mellitus Type II. Ann Path Lab Med. 2016;03(6):567-72.
  21. Khoharo HK, Nizamani GS and Shaikh DM. Mean Platelet Volume in Type 2 Diabetes Mellitus. Elixir Physio Anatomy. 2014;71:25017-20.
  22. Ünübol Ayhan M, Güney E. The relationship between mean platelet volume with microalbuminuria and glycemic control in patients with type II diabetes mellitus. Platelets 2012;23(6):475 80.
  23. Akinsegun A, Olusola DA, Sarah JO, Olajumoke O, Adewumi A, Majeed O, et al. Mean platelet volume and platelet counts in type 2 diabetes: mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria. Pan Afr Med J. 2014;18:42. PMC4215377.
  24. Liu J,,Liu,X, Li Y, Quan J, Wei S, An S, Yang R and Liu J. The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis. Bioscience Reports. 2018; 38(3):BSR20180172.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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