Review Article

Granulomatosis with Polyangiitis (GPA) / Wegner's Granulomatosis: A Summary of Clinical Issues

Asif Hussain1
Australian Medical Council, Epping Medical Specialist Centre
Muhammad M Javaid2
Monash University, Southwest Regional Hospital, Victoria, Australia
Jawaria Avais1
Australian Medical Council, Epping Medical Specialist Centre

✉ Correspondence: Asif Hussain Email: drasifhussain@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i4.2164
Volume: 2, Issue 4 Pages: 284–292 Published: 14 Dec 2021
Received: 04 Sep 2021 Accepted: 06 Oct 2021 Published Online: 14 Dec 2021

Abstract

Vasculitis can mimic many diseases; often, there are delays in diagnosis and often ends up in life/organ threatening complications without proper diagnosis and timely treatment. Patients can present with various combinations of constitutional symptoms, vasculitic symptoms, and organ involvements. ANCA tests also have many false positive and false negative results, which adds to the complexity. In addition, Anti-neutrophilic Cytoplasmic Antibody (ANCA) associated Vasculitis (AAV) have different pathological and clinical manifestations from other Vasculitis. There are four types of AAV, including Granulomatosis with Polyangiitis (GPA, previously known as Wegner's Granulomatosis), Microscopic Polyangiitis (MPA), Eosinophilic Granulomatosis with Polyangiitis (E-GPA, previously called as Churg Strauss Vasculitis), and Renal Limited / Organ limited ANCA associated Vasculitis

Keywords
Granulomatosis with Polyangiitis Wegner's granulomatosis ANCA associated Vasculitis Small Vessel Vasculitis Pauci-Immune Vasculitis

How to Cite This Article

Hussain A, Javaid MM, Avais J. Granulomatosis with Polyangiitis (GPA) / Wegner's Granulomatosis: A Summary of Clinical Issues. J Pak Soc Intern Med. 2021;2(4):284–292. doi:10.70302/jpsim.v2i4.2164

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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