Original Research

Positive Predictive Value of Thrombocytopenia and Leukopenia in Diagnosis of Acute Dengue Infection

Rafia Behzad
Fauji Foundation Hospital, Rawalpindi
Aatika Khalid
Fauji Foundation Hospital, Rawalpindi

✉ Correspondence: Rafia Behzad Email: dr.waqas099@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i4.2167
Volume: 2, Issue 4 Pages: 304–307 Published: 14 Dec 2021
Received: 17 Aug 2021 Accepted: 02 Nov 2021 Published Online: 14 Dec 2021

Abstract

Objective

To determine the positive predictive value of thrombocytopenia and leukopenia in patients of acute dengue
infection.

Methods

This descriptive study was undertaken in Haematology Department, Medical and Pediatric wards, Fauji
Foundation Hospital, Rawalpindi. A total of 100 patients diagnosed as a case of acute dengue infection on the basis of
Indirect ELISA for anti DENV IgM were selected using inclusion and exclusion criteria. Venous blood of 2.5 ml of these
patients was collected in CP bottle containing EDTA as anticoagulant. It was analyzed on automated Haematology
analyzer Sysmex XT 2000i system. Blood levels of Total Leucocyte Count and platelet count were recorded and
documented for these patients and their positive predictive values were calculated.

Results

Out of 100 diagnosed patients of acute dengue infection, 81% exhibited thrombocytopenia and 75% had
leukopenia. The combined PPVof leukopenia and thrombocytopenia was 88%.

Conclusion

Acute dengue fever is characterized by thrombocytopenia and leukopenia. Therefore Dengue should be the
top most differential diagnosis in febrile patients with thrombocytopenia and leucopenia.

Keywords
Acute dengue infection Positive predictive value (PPV) Leukopenia Thrombocytopenia.

How to Cite This Article

Behzad R, Khalid A. Positive Predictive Value of Thrombocytopenia and Leukopenia in Diagnosis of Acute Dengue Infection. J Pak Soc Intern Med. 2021;2(4):304–307. doi:10.70302/jpsim.v2i4.2167

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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