Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Diagnosing Carcinoma Prostate

Nazia Aslam; Sadaf Arooj; Saima Ameer; Maria Imdad; Mahwish Mansoor; Riffat Raja

doi:10.70302/jpsim.v2i4.2170

Original Research

Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Diagnosing Carcinoma Prostate

Nazia Aslam¹

Punjab Institute of Neurosciences, Lahore

Sadaf Arooj¹

Punjab Institute of Neurosciences, Lahore

Saima Ameer²

Lahore General Hospital, Lahore

Maria Imdad¹

Punjab Institute of Neurosciences, Lahore

Mahwish Mansoor³

Bolan Medical College,Quetta

Riffat Raja⁴

Holy family hospital, Rawalpindi

✉ Correspondence: Sadaf Arooj Email: sadafarooj@hotmail.com

DOI https://doi.org/10.70302/jpsim.v2i4.2170

Volume: 2, Issue 4 Pages: 316–319 Published: 14 Dec 2021

Received: 22 Aug 2021 Accepted: 02 Dec 2021 Published Online: 14 Dec 2021

Abstract

Objective

To determine the diagnostic accuracy of magnetic resonance spectroscopy (MRS) in detection of prostate cancer, rendering histopathology as gold standard.

Methods

Descriptive, Cross sectional study conducted from January 2016 to June 2017. Total 206 male patients with clinical suspicion of carcinoma prostate were included in study. Magnetic resonance spectroscopy (MRS) was performed in each patient. The findings were correlated with histopathology report to confirm the diagnosis.

Results

Out of 206 cases, MRS supported the diagnosis of prostate cancer in 120 (58.25%) patients. Histopathology confirmed prostate cancer in 124 (60.19%) cases whereas 82 (39.81%) patients revealed no prostate cancer. Overall sensitivity, specificity and diagnostic accuracy of magnetic resonance spectroscopy (MRS) in diagnosing carcinoma prostate was 87.10%, 85.37% and 86.41% respectively.

Conclusion

Magnetic resonance spectroscopy has high diagnostic accuracy in diagnosing prostate cancer.

Keywords

Magnetic resonance spectroscopy has high diagnostic accuracy in diagnosing prostate cancer.

How to Cite This Article

Aslam N, Arooj S, Ameer S, Imdad M, Mansoor M, Raja R. Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Diagnosing Carcinoma Prostate. J Pak Soc Intern Med. 2021;2(4):316–319. doi:10.70302/jpsim.v2i4.2170

⭳ Download PDF

Download Citation: ⭳ RIS (Endnote / Zotero / Mendeley) ⭳ BibTeX (.bib)

Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

Rasool M, Pansota MS, Tabassum SA, Saleem MS. Frequency of carcinoma of prostate in clinically benign prostatic hyperplasia and role of different screening tests. Pak Armed Forces Med J. 2010;62(3):431-4.
Roethke M, Anastasiadis AG, Lichy M, Werner M, Wagner P, Kruck S, et al. MRI guided prostate biopsy detects clinically significant cancer: analysis of a cohort of 100 patients after previous negative biopsy. World J Urol. 2012;30(2):213-8.
Hambrock T, Somford DM, Hoeks C, Bouwense SA, H uisman H , Yakar D et al. Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen. J Urol.2010;183(2):520-7
Caivano R, Cirillo P, Balestra A, Lotumolo A, Fortunato G, Macarini L, et al. Prostate cancer in magnetic resonance imaging: diagnostic utilities of spectroscopies sequences. J Med Imaging Radiat Oncol. 2102;56(6):606-16.
Rosario DJ, Lane JA, Metcalfe C, Donovan JL, Doble A. Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study. Br Med J. 2012:344;d7894
Ackerstaff E, Pflug BR, Nelson JB. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res. 2001;61(9):3599-603.
Testa C, Schiavina R, Lodi R, Salizzoni E, Tonon C, D’Errico A, et al. Accuracy of MRI/MRSI based transrectal ultrasound biopsy in peripheral and transition zones of the prostate gland in patients with prior negative biopsy. NMR Biomed. 2010;23(9):1017-26.
Zakian KL, Eberhardt S, Hricak H. Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging – initial results. Radiology. 2003;229(1):241-7.
Yuen JS, Thng CCH, Tan PH. Endorectal magnetic resonance imaging and spectroscopy for the detection of tumor foci in men with prior negative transrectal ultrasound prostate biopsy. J Urol. 2004;171(4):1482-6
Prando A, Kurhanewicz J, Borges Ap. Prostatic biopsy directed with endorectal MR spectroscopic imaging findings in patients with elevated prostate specific antigen levels and prior negative biopsy findings: early experience. Radiology.2005;236(3):903-10
Weinreb JC, Blume JD, Coakley FV et al. Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy – results of ACRIN prospective multi - institutional clinicopathologic study. Radiology 2009;251(1):122-33
Hasumi M, Suzuki K, Oya N, Ito K, Kurokawa K, Fukabori Y, Yamanaka H. MR spectroscopy as a reliable diagnostic tool for localization of prostate cancer. Anticancer Res. 2002;22(2B): 1205-8.
Bong Hee Park, Hwang G. Jeon, Seol Ho Choo, Byong Chang Jeong, Seong Il Seo, Seong S. Jeon, Han Y. Choi, Hyun Moo Lee. Role of multiparametric 3.0-Tesla magnetic resonance imaging in patients with prostate cancer eligible for active surveillance. BJU Int volume. 2013;113(6):864-70.

Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.

📃 In This Issue View All

Original Article Cervical Cancer Screening Awareness Among Rural Women in Punjab Bibi S, Anjum R, Hassan F Review Article Antibiotic Resistance Patterns in Community-Acquired Pneumonia: Emerging Trends Hussain I, Farooq Z Original Article Prevalence of Hypertension Among Urban Adults in Pakistan: A Cross-Sectional Study Khan TM, Ahmed S, Malik RA Original Article Impact of Diabetes Mellitus on Post-Operative Wound Healing in General Surgery Siddiqui FA, Noor M, Akhtar W Original Article Comparison of Ultrasound-Guided versus Landmark-Based Central Venous Catheter Insertion Zafar S, Gillani SA

👥 More by These Authors

Review Article Statin Therapy in Non-Alcoholic Fatty Liver Disease: A Systematic Review Nawaz F, Cheema HA, Mehmood Y Original Article Serum Ferritin as a Prognostic Marker in COVID-19 Severity: A Hospital-Based Study Rehman N, Sheikh I, Javed K Original Article Outcomes of Laparoscopic Cholecystectomy in Acute Cholecystitis: A Retrospective Analysis Raza SH, Butt N, Qureshi AM Review Article Thyroid Disorders in Pregnancy: Clinical Implications and Management Strategies Baig BI, Usman A

🔗 Related Articles By Keywords

Original Article Prevalence of Hypertension Among Urban Adults in Pakistan: A Cross-Sectional Study Khan TM, Ahmed S, Malik RA Original Article Impact of Diabetes Mellitus on Post-Operative Wound Healing in General Surgery Siddiqui FA, Noor M, Akhtar W Original Article Comparison of Ultrasound-Guided versus Landmark-Based Central Venous Catheter Insertion Zafar S, Gillani SA Original Article Neonatal Sepsis: Bacteriological Profile and Antibiogram in a Tertiary Care Hospital Iqbal M, Rashid T

[1] Rasool M, Pansota MS, Tabassum SA, Saleem MS. Frequency of carcinoma of prostate in clinically benign prostatic hyperplasia and role of different screening tests. Pak Armed Forces Med J. 2010;62(3):431-4.

[2] Roethke M, Anastasiadis AG, Lichy M, Werner M, Wagner P, Kruck S, et al. MRI guided prostate biopsy detects clinically significant cancer: analysis of a cohort of 100 patients after previous negative biopsy. World J Urol. 2012;30(2):213-8.

[3] Hambrock T, Somford DM, Hoeks C, Bouwense SA, H uisman H , Yakar D et al. Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen. J Urol.2010;183(2):520-7

[4] Caivano R, Cirillo P, Balestra A, Lotumolo A, Fortunato G, Macarini L, et al. Prostate cancer in magnetic resonance imaging: diagnostic utilities of spectroscopies sequences. J Med Imaging Radiat Oncol. 2102;56(6):606-16.

[5] Rosario DJ, Lane JA, Metcalfe C, Donovan JL, Doble A. Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study. Br Med J. 2012:344;d7894

[6] Ackerstaff E, Pflug BR, Nelson JB. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res. 2001;61(9):3599-603.

[7] Testa C, Schiavina R, Lodi R, Salizzoni E, Tonon C, D’Errico A, et al. Accuracy of MRI/MRSI based transrectal ultrasound biopsy in peripheral and transition zones of the prostate gland in patients with prior negative biopsy. NMR Biomed. 2010;23(9):1017-26.

[8] Zakian KL, Eberhardt S, Hricak H. Transition zone prostate cancer: metabolic characteristics at 1H MR spectroscopic imaging – initial results. Radiology. 2003;229(1):241-7.

[9] Yuen JS, Thng CCH, Tan PH. Endorectal magnetic resonance imaging and spectroscopy for the detection of tumor foci in men with prior negative transrectal ultrasound prostate biopsy. J Urol. 2004;171(4):1482-6

[10] Prando A, Kurhanewicz J, Borges Ap. Prostatic biopsy directed with endorectal MR spectroscopic imaging findings in patients with elevated prostate specific antigen levels and prior negative biopsy findings: early experience. Radiology.2005;236(3):903-10

[11] Weinreb JC, Blume JD, Coakley FV et al. Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy – results of ACRIN prospective multi - institutional clinicopathologic study. Radiology 2009;251(1):122-33

[12] Hasumi M, Suzuki K, Oya N, Ito K, Kurokawa K, Fukabori Y, Yamanaka H. MR spectroscopy as a reliable diagnostic tool for localization of prostate cancer. Anticancer Res. 2002;22(2B): 1205-8.

[13] Bong Hee Park, Hwang G. Jeon, Seol Ho Choo, Byong Chang Jeong, Seong Il Seo, Seong S. Jeon, Han Y. Choi, Hyun Moo Lee. Role of multiparametric 3.0-Tesla magnetic resonance imaging in patients with prostate cancer eligible for active surveillance. BJU Int volume. 2013;113(6):864-70.