Original Research

Comparison of Carvedilol and Endoscopic Band Ligation for the Prevention of Variceal Bleed in Patients of Cirrhosis

Muhammad Shoaib Khan1
Sir Ganga Ram Hospital, Lahore
Zafar Niaz2
King Edward Medical University/Mayo Hospital
Sami Ullah Mumtaz2
King Edward Medical University/Mayo Hospital
Areej Azhar Siddiqui3
Saeeda Wajahat Foundation, Lahore
Somia Iqtadar2
King Edward Medical University/Mayo Hospital
Sajid Abaidulla2
King Edward Medical University/Mayo Hospital

✉ Correspondence: Sami Ullah Mumtaz Email: drsummumtaz@gmail.com

DOI https://doi.org/10.70302/jpsim.v2i4.2173
Volume: 2, Issue 4 Pages: 327–329 Published: 14 Dec 2021
Received: 09 Sep 2021 Accepted: 06 Dec 2021 Published Online: 14 Dec 2021

Abstract

Objective

To compare carvedilol & endoscopic band ligation (EBL) for the prevention of variceal bleed in patients of
cirrhosis.

Methods

This was a randomized control trial done at North Medical Unit, Mayo Hospital, Lahore from 1st December
2016 to 30th May 2017. After ethical approval of study, 250 patients of cirrhosis were taken through non-probability
purposive sampling technique. Informed consent was taken from each patient. After taking demographic details patients
were randomly divided into two groups by using simple lottery method. In group A, patients received carvedilol 12.5mg
daily orally and in group B, EBL was done using a multibander device. Then patients were followed for 6 months
afterwards for variceal bleed. The frequency of variceal bleed in two groups was compared by using Chi square test. Pvalue < 0.05 was considered significant.

Results

The mean age was 53.06±14.50 years. There were 41.2% females & 58.8% males. Variceal bleed (VB) was
observed in 22 patients in which 6 patients were of carvedilol group and 16 were of EBL group. There was significant
difference between two groups in response to therapy of VB i.e. p-value=0.026 was significant.

Conclusion

Carvedilol was more effective for VB prevention as compared to EBLin cirrhotic patients

Keywords
Variceal Bleed Comparison Carvedilol Endoscopic Band Ligation Cirrhosis.

How to Cite This Article

Khan MS, Niaz Z, Mumtaz SU, Siddiqui AA, Iqtadar S, Abaidulla S. Comparison of Carvedilol and Endoscopic Band Ligation for the Prevention of Variceal Bleed in Patients of Cirrhosis. J Pak Soc Intern Med. 2021;2(4):327–329. doi:10.70302/jpsim.v2i4.2173

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2021 Journal of Pakistan Society of Internal Medicine.
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