Original Research

Diagnostic accuracy of ultrasonography for diagnosis of congenital hypothyroidism in neonates taking scintigraphy as gold standard

Irfan Sharif1
Tehsil Head Quarter Hospital Dunyapur
Tayyab Javed2
Rural Health Center Manawala
Jawairia Aslam3
Hilal-e-Ahmer Hospital, Faisalabad
Iqra Waheed4
Private Services Lahore

✉ Correspondence: Irfan Sharif Email: irfanmalik210@gmail.com

DOI https://doi.org/10.70302/jpsim.v3i3.2245
Volume: 3, Issue 3 Pages: 230–232 Published: 12 Sep 2022
Received: 27 Mar 2022 Accepted: 08 Jul 2022 Published Online: 12 Sep 2022

Abstract

Objective

To assess the diagnostic accuracy of ultrasonography for diagnosis of congenital hypothyroidism in neonates taking scintigraphy as gold standard.

Methods

This Cross-sectional, validation study was undertaken in Department of Pediatrics, Mayo Hospital, Lahore during August2017 to February 2018. A total of 202 neonates who met the inclusion criteria were included in the study. Then neonates underwent thyroid ultrasonography. Neonates were labeled as positive or negative for congenital hypothyroidism. Then all neonates underwent scintigraphy as per hospital protocol. Reports were assessed and neonates were confirmed as positive or negative for congenital hypothyroidism. All data was entered in specially designed Performa. The data was analyzed in SPSS version 20.

Results

The mean age of neonates was 13.02±7.55days. There were 97 (48%) males and 105 (52%) females. The mean weight of neonates was 2.28±0.39kg. On ultrasound, 76 (37.6%) neonates who have congenital hypothyroidism while 126 (62.4%) neonates had normal thyroid levels. On scintigraphy, 85 (42.1%) neonates who have congenital hypothyroidism while 117 (57.9%) neonates had normal thyroid levels. The sensitivity of ultrasound was 82.4%, “specificity was 94.9%, PPV was 92.1%, NPV was 88.1% and diagnostic accuracy was” 89.6% respectively taking scintigraphy as gold standard.

Conclusion

Thus the ultrasound is accurate enough that it can detect congenital hypothyroidism instead of going for interventional procedure of scintigraphy, which includes radioactive material.

Keywords
Ultrasonography congenital hypothyroidism neonates scintigraphy

How to Cite This Article

Sharif I, Javed T, Aslam J, Waheed I. Diagnostic accuracy of ultrasonography for diagnosis of congenital hypothyroidism in neonates taking scintigraphy as gold standard. J Pak Soc Intern Med. 2022;3(3):230–232. doi:10.70302/jpsim.v3i3.2245

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2022 Journal of Pakistan Society of Internal Medicine.
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