Original Research

Assessment of Clinical Efficacy of Early Use of Remdesivir in ThePatients of COVID-19 Pneumonia

Atif Mahmood
Department of Pulmonology Fatima Memorial Hospital
Asma Khan
Department of Pulmonology Fatima Memorial Hospital
Ayesha Shahbaz
Department of Pulmonology Fatima Memorial Hospital
Saira Pervaiz
Department of Pulmonology Fatima Memorial Hospital

✉ Correspondence: Asma Khan Email: afzal.a3s3@gmail.com

DOI https://doi.org/10.70302/jpsim.v4i2.2323
Volume: 4, Issue 2 Pages: 111–115 Published: 02 Jun 2023
Received: 18 Feb 2023 Accepted: 12 Apr 2023 Published Online: 02 Jun 2023

Abstract

Objective

Primary objective of the study is to evaluate the clinical efficacy of early use of Remdesivir in reducing the progression and severity of Covid-19 pneumonia.

Methods

This retrospective study was undertaken in Pulmonology department, Fatima Memorial Hospital, Lahore. After taking history and doing physical examination, loading dose of 200mg intravenous Remdesivir was given to the 350 patients of COVID-19 pneumonia followed by 100mg intravenous dose given once a day for five days. During treatment assessment of clinical efficacy of Remdesivir was evaluated along with viral clearance rate and evaluation of side effects of therapy. These were documented on preformed Performa.

Results

The results showed 99.9% efficacy in patients with Covid-19 pneumonia who were treated with early Remdesivir. Paired sample t-test showed statistical significant results in radiological findings and oxygen saturation pre and post Remdesivir therapy. Almost all the clinical symptoms got relieved after therapy. Drug related side effects were reported in 21 individuals (6%).

Conclusion

The early introduction of drug Remdesivir to the treatment of Covid-19 PCR positive patients has been suggested as a more efficacious strategy for treating Covid-19 pneumonia.

Keywords
Remdesivir Covid-19 anti-viral

How to Cite This Article

Mahmood A, Khan A, Shahbaz A, Pervaiz S. Assessment of Clinical Efficacy of Early Use of Remdesivir in ThePatients of COVID-19 Pneumonia. J Pak Soc Intern Med. 2023;4(2):111–115. doi:10.70302/jpsim.v4i2.2323

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2023 Journal of Pakistan Society of Internal Medicine.
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