Case Report

Cannabis Abuse and Cerebral Venous Sinus Thrombosis (CVST) inMale Patients

Mazhar Hamdani
Abbas Institute of Medical Sciences, AJK Medical College, Muzaffarabad
Abdul Khalid
Abbas Institute of Medical Sciences, AJK Medical College, Muzaffarabad
Ayesha Ishaq
Abbas Institute of Medical Sciences, AJK Medical College, Muzaffarabad
Muhammad Arshad
Abbas Institute of Medical Sciences, AJK Medical College, Muzaffarabad

✉ Correspondence: Abdul Khalid Email: abdulkhalid301@gmail.com

DOI https://doi.org/10.70302/jpsim.v4i2.2330
Volume: 4, Issue 2 Pages: 145–148 Published: 02 Jun 2023
Received: 14 Jan 2023 Accepted: 14 Mar 2023 Published Online: 02 Jun 2023

Abstract

Cannabis is among the most commonly used psychoactive substance in the world1. Smoking Cannabis is common in the cultural events of Sub-Continent and some visitors smoke it over shrines during the festivals. A 37- years old male, married, driver by profession, the only earner of his family with three dependents, presented in emergency department (ED) in January 2022 with severe, diffuse, thunderclap and non-resolving headache for the last two days. He used oral diclofenac sodium for one day without medical advice and there was no improvement in the headache. He was a smoker and also smoked cannabis during last one month and smoked cannabis in amounts more than his usual routine. On examination, his blood complete picture showed TLC 11.7 ×10³/cubic millimeter (cmm), Hb.15.3 gm/dl, PLT 180 × 10³ / cmm, total bilirubin 1.2 mg/dl,ALP260 U/L,ALT39 U/L, Urea 36 mg/dl, Creatinine 0.8 mg/dl and erythrocyte sedimentation rate was 30 mm in 1st hour. He was treated with Enoxaparin, Tramadol and Metoclopramide. Naproxen Sodium and Normal Saline were given on day one only. Patient significantly improved after 5 days of treatment and was discharged on direct oral anticoagulants.

How to Cite This Article

Hamdani M, Khalid A, Ishaq A, Arshad M. Cannabis Abuse and Cerebral Venous Sinus Thrombosis (CVST) inMale Patients. J Pak Soc Intern Med. 2023;4(2):145–148. doi:10.70302/jpsim.v4i2.2330

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. United Nations Office on Drugs and Crime. World Drug Report. Executive Summary. Conclusions and Policy Implications (2018)
  2. Sorkhou M, Bedder RH, George TP. The behavioral sequelae of cannabis use in healthy people: a systematic review. Front Psychiat. 2021;12(1):630247.
  3. Panlilio LV, Ferré S, Yasar S, Thorndike EB, Schindler CW, Goldberg SR. Combined effects of THC and caffeine on working memory in rats. Br J Pharmacol. 2012; 165(12):2529–38.
  4. Swetlik C, Migdady I, Hasan LZ, Buletko AB, Price C, Cho SM. Cannabis Use and Stroke: Does a Risk Exist? J Addict Med. 2022;16(2):208-15.
  5. García-Azorín D, Monje MH, González-García N, Guerrero ÁL, Porta-Etessam J. Presence of red flags in patients with cerebral venous sinus thrombosis admitted to the emergency department because of headache: A STROBE compliant cohort-study. Medicine. 2020; 99(29):(e20900).
  6. Dentali F, Poli D, Scoditti U, et al. Long-term outcomes of patients with cerebral vein thrombosis: a multicenter study. J Thromb Haemostasis. 2012;10(5):1297–302.
  7. Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F. Prognosis of cerebral vein and dural sinus thrombosis. Results of the international study on cerebral vein and dural sinus thrombosis. Stroke. 2004;35(3):664–70.
  8. Komro J, Findakly D: Cerebral venous sinus thrombosis in adults with prothrombotic conditions: a systematic review and a case from our institution. Cureus. 2020; doi:10.7759/cureus.7654. doi:10.7759/cureus.7654
  9. Findakly D, Komro J. Not Just Another Headache: Cerebral Venous Sinus Thrombosis in a Patient With Isolated Antithrombin III Deficiency. Cureus. 2020;12 (5): e8383. doi:10.7759/cureus.8383. doi:10.7759/cureus.8383
  10. Luo Y, Tian X and Wang X. Diagnosis and treatment of cerebral venous thrombosis: a review. Frontiers Aging Neurosci. 2018; 10(1): 2.
  11. Morgan CJ, Freeman TP, Hindocha C, Schafer G, Gardner C, Curran HV. Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory function. Transl Psychiatry. 2018; doi: 10.1038/s41398-018-0191-x. doi:10.1038/s41398-018-0191-x
  12. Lowe DJ, Sasiadek JD, Coles AS, George TP. Cannabis and mental illness: a review. Eur Arch Psychiatry Clin Neurosci. 2019;269(1):107–20.
  13. Becker MP, Collins PF, Schultz A, Uroševi´c S, Schmaling B, Luciana M. Longitudinal changes in cognition in young adult cannabis users. J Clin Exp Neuropsychol. 2018;40(3):529-43.
  14. Jonathan M. Coutinho, , José M. Ferro, Patrícia Canhão. Cerebral Venous and Sinus Thrombosis in Women. Stroke. 2009;40(7):2356-61.

Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2023 Journal of Pakistan Society of Internal Medicine.
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