Original Research

Frequency of Esophageal Varices in Chronic Liver Disease Patients & its Relationship to Mean of Ratio of Right Lobe of Liver to Serum Albumin Concentration

DOI https://doi.org/10.70302/jpsim.v4i3.2342
Received: 24 Apr 2023 Accepted: 15 Jun 2023 Published Online: 25 Sep 2023

Abstract

Objective

Aim of present study is to find the frequency of esophageal varices in CLD patients & its relationship to the mean of ratio of right lobe of liver to serum albumin concentration.

Methods

This cross sectional study was completed in Department of Gastroenterology, Mayo Hospital Lahore in six months. After ethical approval, 200 diagnosed patients of CLD recruited using non-probability purposive sampling technique. An informed written consent was acquired from each patient & endoscopy was done for the presence of esophageal varices, ultrasonography to measure right lobe of liver and serum sample to check albumin levels. All patients were then divided in two groups’ i.e. esophageal varices (A) and other without varices (B). The ratio of right lobe of liver to serum albumin concentration was calculated for both groups. Data was analyzed using SPSS Version 26.0.

Results

Out of 200 patients, 109 (54.5%) had esophageal varices while 91(45.5%) had no varices while mean ratio of right lobe of liver and serum albumin concentration among the two groups revealed high ratio in esophageal varcies group as compare to without varices group i.e. 39.92+7.43 versus 34.53+5.27 respectively.

Conclusion

The frequency of esophageal varices was high in CLD patients while mean of ratio of right lobe of liver to serum albumin concentration was markedly high among patients having varices compared to those lacking varices.

Keywords
Chronic liver disease esophageal varices mean ratio right lobe of liver Serum albumin concentration

How to Cite This Article

Saeed MF, Mumtaz SU, Nawaz K, Aziz B, Nazar T, Maqsood S. Frequency of Esophageal Varices in Chronic Liver Disease Patients & its Relationship to Mean of Ratio of Right Lobe of Liver to Serum Albumin Concentration. J Pak Soc Intern Med. 2023;4(3):210–213. doi:10.70302/jpsim.v4i3.2342

⭳ Download PDF

Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. Mcphee JS, Papdakies AM. Cirrhosis. In: Lawrence M. Tierney, Jr, editor. Current Medical Diagnosis And Treatment. New York: McGraw-Hill; 2008;584-8.
  2. Amico GD, Morabito A. Noninvasive markers of esophageal varices: Another round, not the last. Hepatol. 2004;39(1):30-4.
  3. Jensen DM. Endoscopic screening for varices in cirrhosis: findings implications, and outcomes. Gastroenterol. 2002;122(8):1620-30.
  4. Grace ND. Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. American College Of Gastroenterology Practice Parameter Committee. Am J Gastroenterol. 1997;92(6):1081-91.
  5. Sarwar S, Khan AA, Butt AK, Shafqat F, Malik K, Ahmad I. Non-endoscopic prediction of esophageal varices in cirrhosis. J Coll Physicians Surg Pak. 2005;15(3):528-31.
  6. Agha A, Anwar E, Bashir K, Savarino V, Giannini EG. External validation of the platelet count /spleen diameter ratio for the diagnosis of esophageal varices in hepatitis C virus-related cirrhosis. Dig Dis Sci 2009;54(4):654-60.
  7. Khuram M, Khan NY, Arif M, Irshad MM, Hammatul Bushra K, Hassan Z. Association of platelet count to splenic index ratio with presence of esophageal varices in patients with Hepatitis C virus related compensated cirrhosis. Pak J Gastroenterol. 2006;20(1):37-42.
  8. Khan H, Iman N. Hypoalbuminemia: a marker of oesophageal varices in chronic liver disease due to hepatitis B and C. Rawal Med J. 2009;34(1):98-101.
  9. Alempijevic T, Kovacevic N. Right liver lobe diameter: albumin ratio: a new non-invasive parameter for prediction of oesophageal varices in patients with liver cirrhosis (preliminary report). Gut. 2007;56(5):1166-7.
  10. Mahmoud AA, Riad GS. A novel non-invasive Ratio for oesophageal varices prediction in HCV- liver cirrhosis Egyptian patients. J Am Science. 2011;7(1):13-9.
  11. Jensen DM. Endoscopic screening for varices in cirrhosis: findings, implications, and outcomes. Gastroenterol. 2002;122(60):1620-30.

Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2023 Journal of Pakistan Society of Internal Medicine.