Review Article

Role of Combination of Sacubitril and Valsartan for Management of Patients with Decompensated Heart Failure

Waqar Ahmad
Department of Cardiology, Mayo Hospital, Lahore
Anas Sajjad
Department of Cardiology, Mayo Hospital, Lahore
Farwa Abbas
Department of Cardiology, Mayo Hospital, Lahore
Amna Riaz
Department of Cardiology, Mayo Hospital, Lahore
Rae Hasnain Shehzad
Department of Cardiology, Mayo Hospital, Lahore
Iqra Waheed
Department of Cardiology, Mayo Hospital, Lahore

✉ Correspondence: Waqar Ahmad Email: doc_waqar10@yahoo.com

DOI https://doi.org/10.70302/jpsim.v4i3.2343
Volume: 4, Issue 3 Pages: 214–217 Published: 25 Sep 2023
Received: 03 Jun 2023 Accepted: 20 Jul 2023 Published Online: 25 Sep 2023

Abstract

Objective

To determine the outcome of sacubitril plus valsartan in patients with decompensated heart failure

Methods

This quasi experimental study was done at Department of Cardiology, Mayo Hospital, Lahore during March 2022 to March 2023. Total 200 patients with decompensated heart failure were enrolled through emergency and admitted in cardiology wards. All patients were given Sacubitril / valsartan (200 mg, twice daily) during hospital stay. Then all patients were followed-up until discharge from the hospital. If patient died during hospital stay, then mortality was noted. data was colelcted in proforma whiel analysed in SPSS version 25.

Results

In this trial, we enrolled total 200 individuals with decompensated heart failure with mean age of 55.02 ± 8.64 years. Out of 200 individuals, 111 (55.5%) were males and 89 (44.5%) were females. Out of 200 individuals, 34 (17.0%) individuals died during follow-up in the hospital after receiving sacubitril with valsartan combination drug. For ejection fraction, the mortality was significantly higher in individuals who had ejection fraction less than 22% (27.9%) as compared to individuals with ejection fraction was higher than 22% (3.4%, p-value < 0.05).

Conclusion

The outcome of sacubitril with valsartan combination drug is better and morality is less.

Keywords
in-hospital mortality sacubitril valsartan decompensated heart failure

How to Cite This Article

Ahmad W, Sajjad A, Abbas F, Riaz A, Shehzad RH, Waheed I. Role of Combination of Sacubitril and Valsartan for Management of Patients with Decompensated Heart Failure. J Pak Soc Intern Med. 2023;4(3):214–217. doi:10.70302/jpsim.v4i3.2343

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2023 Journal of Pakistan Society of Internal Medicine.
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