Original Research

Sodium Imbalance and In-Hospital Mortality in Patients Presenting with Sepsis at Tertiary Care Hospital

Marium Khurshid
Aga Khan University, Karachi
Madiha Iqbal
Aga Khan University, Karachi
Sohail Lakhani
Aga Khan University, Karachi
Zara Nadeem
Aga Khan University, Karachi
Syeda Zeenat Sahar Junaid
Aga Khan University, Karachi
Areesh Mevawalla
Aga Khan University, Karachi
Ainan Arshad
Aga Khan University, Karachi

✉ Correspondence: Marium Khurshid Email: mariumkhurshid.3@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i1.2405
Volume: 5, Issue 1 (Women Issue) Pages: 379–382 Published: 28 Feb 2024
Received: 21 Oct 2023 Accepted: 26 Dec 2023 Published Online: 28 Feb 2024

Abstract

Objective

To determine if presenting hyponatremia in septic patients is associated with higher in-hospital mortality.

Methods

This study was conducted at Aga Khan University Hospital Karachi, in the department of medicine for the duration of 6 months after ERC approval. Sample size of the study was 153 by taking prevalence of severe hyponatremia 15.8%, with margin of error = 6% and CI=95%. Those patients who were admitted with diagnosis of sepsis aged above 20 years were included in the study. Data was collected and recorded in computers, results were generated by using SPSS recent version and analysis was done by analyst.

Results

During the selected time frame for the study 153 patients were included in the study. Table-1 described the patient demographics, clinical characteristic and outcome of the patients included in the study, and comparison has been done amongst the two groups, with and without hyponatremia. Overall mortality in our study was found to be 39%, out of which 43.8% had hyponatremia, and 29.3% were with normal sodium levels. Females comprised of 51.2% of hyponatremic patients and 45.5% of normal serum sodium group. The SOFA score between these two groups did not show any significant difference. Patients with hyponatremia group had prolonged complicated hospital stay and required invasive ventilation (%) and had an increased mortality rate (43.8%) in comparison to patients who had normal sodium levels (29.3%).

Conclusion

Hyponatremia at presentation is not associated with higher in-hospital mortality in patients with sepsis.

Keywords
: Hyponatremia Sepsis Sepsis-3 ICU

How to Cite This Article

Khurshid M, Iqbal M, Lakhani S, Nadeem Z, Junaid SZS, Mevawalla A, et al.. Sodium Imbalance and In-Hospital Mortality in Patients Presenting with Sepsis at Tertiary Care Hospital. J Pak Soc Intern Med. 2024;5(1):379–382. doi:10.70302/jpsim.v5i1.2405

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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