Original Research

Effect of Nebulized Magnesium Sulphate in Terms of the In-HospitalOutcome of Patients Admitted with Acute Exacerbation of ChronicObstructive Pulmonary disease

Qurratul Ain1
Central Park Medical College, Lahore
Fawad Ahmad Randhawa2
King Edward Medical University, Lahore
Nasir Farooq Butt2
King Edward Medical University, Lahore
Ayesha Aslam2
King Edward Medical University, Lahore
Hina Latif2
King Edward Medical University, Lahore
Rabia Rathore2
King Edward Medical University, Lahore

✉ Correspondence: Qurratul Ain Email: qurratulain92@hotmail.com

DOI https://doi.org/10.70302/jpsim.v5i1.2406
Volume: 5, Issue 1 (Women Issue) Pages: 383–387 Published: 28 Feb 2024
Received: 07 Oct 2023 Accepted: 11 Dec 2023 Published Online: 28 Feb 2024

Abstract

Objective

To evaluate the efficacy of Magnesium Sulphate (MgSO4) with the conventional treatment in acute exacerbation chronic obstructive pulmonary disease (AECOPD)

Methods

This Quasi-experimental study was conducted in Department of Internal Medicine from July 2020 to July 2022. The study involved 160 patients in total. There were two groups of patients. Group A was nebulized with 250mg of MgSO4 four times a day along with conventional treatment. Group B was given only conventional treatment. Conventional treatment included oxygen inhalation, anti-cholinergic and beta-2 agonist nebulization, intravenous steroids, and intravenous antibiotics. Both groups were followed for five days to assess the effect of nebulized magnesium.

Results

Group A required assisted ventilation for 2–3 days for 28% of the subjects (22 patients out of 80), while group B required it for 81% of the subjects (65 patients out of 80). In addition, only 9% of patients in group A and 8% of patients in group B needed assisted ventilation for four to five days. In comparison to group A, which had 33% of patients discharged on the fourth day and 20% on the fifth day or later, group B saw 53% of patients discharged on the fourth day and 20% on the fifth day or later. The results showed that PCO2 and peak expiratory flow rate (PEFR) have a significant variance between group A and group B and values have no significant variance between group A and group B on the first day and the last day.

Conclusion

Nebulized supplementation improves in-hospital outcomes in patients presenting with acute exacerbation of COPD as compared to the patients not receiving nebulized magnesium sulphate.

Keywords
Acute exacerbation Chronic Obstructive Pulmonary Disease (COPD) Nebulized Magnesium Sulphate

How to Cite This Article

Ain Q, Randhawa FA, Butt NF, Aslam A, Latif H, Rathore R. Effect of Nebulized Magnesium Sulphate in Terms of the In-HospitalOutcome of Patients Admitted with Acute Exacerbation of ChronicObstructive Pulmonary disease. J Pak Soc Intern Med. 2024;5(1):383–387. doi:10.70302/jpsim.v5i1.2406

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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