Original Research

Lactate Dehydrogenase as a Predictor of Disease Severity in Coronavirus Disease (Covid-19)

Tayyeba Komal1
King Edward Medical University, Mayo hospital, Lahore
Sami Ullah Mumtaz1
King Edward Medical University, Mayo hospital, Lahore
Sana Rafique1
King Edward Medical University, Mayo hospital, Lahore
Akhtar Ali2
Shalamar Medical and Dental College, Shalamar Hospital, Lahore
Somia Iqtadar1
King Edward Medical University, Mayo hospital, Lahore
Israr Ul Haque1
King Edward Medical University, Mayo hospital, Lahore

✉ Correspondence: Tayyeba Komal Email: drtksami@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i1.2410
Volume: 5, Issue 1 (Women Issue) Pages: 404–406 Published: 28 Feb 2024
Received: 12 Oct 2023 Accepted: 16 Dec 2023 Published Online: 28 Feb 2024

Abstract

Objective

To find out association between serum lactate dehydrogenase levels and coronavirus disease severity.

Methods

It was a cross sectional study done at mayo hospital Lahore for six months.100 patients of age 15-80 years of either gender having COVID-19 PCR positive were included. Serum LDH levels were sent at the time of admission, day 7 & day 14 to the pathology laboratory KEMU.To assess clinical severity of coronavirus disease, all the enrolled patients were categorized as mild, moderate, severe & critical cases on the basis of oxygen/mechanical ventilation requirement .Data was analyzed using SPSS-26.

Results

A very strong positive correlation observed between serum LDH level a severity of corona virus disease i.e. r = 0.906, p-value < 0.00001. LDH showed Sensitivity 59.52%, Positive Predictive Value 30.12% and Diagnostic Accuracy 25%.

Conclusion

LDH is a strong predictor of COVID-19 disease severity. Thereforein future LDH can be used to see disease severity.

Keywords
: Lactate Dehydrogenase Predictor Severity COVID-19

How to Cite This Article

Komal T, Mumtaz SU, Rafique S, Ali A, Iqtadar S, Haque IU. Lactate Dehydrogenase as a Predictor of Disease Severity in Coronavirus Disease (Covid-19). J Pak Soc Intern Med. 2024;5(1):404–406. doi:10.70302/jpsim.v5i1.2410

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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